Literature DB >> 24777061

Role of polymerase β in complementing aprataxin deficiency during abasic-site base excision repair.

Melike Cağlayan1, Vinod K Batra1, Akira Sassa1, Rajendra Prasad1, Samuel H Wilson1.   

Abstract

DNA polymerase β (pol β) lyase removal of 5'-deoxyribose phosphate (5'-dRP) from base excision repair (BER) intermediates is critical in mammalian BER involving the abasic site. We found that pol β also removes 5'-adenylated dRP from BER intermediates after abortive ligation. The crystal structure of a human pol β-DNA complex showed the 5'-AMP-dRP group positioned in the lyase active site. Pol β expression rescued methyl methanesulfonate sensitivity in aprataxin (hnt3)- and FEN1 (rad27)-deficient yeast.

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Year:  2014        PMID： 24777061      PMCID： PMC6168318          DOI： 10.1038/nsmb.2818

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  19 in total

1.  UCSF Chimera--a visualization system for exploratory research and analysis.

Authors:  Eric F Pettersen; Thomas D Goddard; Conrad C Huang; Gregory S Couch; Daniel M Greenblatt; Elaine C Meng; Thomas E Ferrin
Journal:  J Comput Chem       Date:  2004-10       Impact factor: 3.376

2.  Identification and properties of the catalytic domain of mammalian DNA polymerase beta.

Authors:  A Kumar; J Abbotts; E M Karawya; S H Wilson
Journal:  Biochemistry       Date:  1990-08-07       Impact factor: 3.162

3.  Substrate channeling in mammalian base excision repair pathways: passing the baton.

Authors:  Rajendra Prasad; David D Shock; William A Beard; Samuel H Wilson
Journal:  J Biol Chem       Date:  2010-10-14       Impact factor: 5.157

4.  Actions of aprataxin in multiple DNA repair pathways.

Authors:  Ulrich Rass; Ivan Ahel; Stephen C West
Journal:  J Biol Chem       Date:  2007-02-02       Impact factor: 5.157

5.  Functional analysis of the amino-terminal 8-kDa domain of DNA polymerase beta as revealed by site-directed mutagenesis. DNA binding and 5'-deoxyribose phosphate lyase activities.

Authors:  R Prasad; W A Beard; J Y Chyan; M W Maciejewski; G P Mullen; S H Wilson
Journal:  J Biol Chem       Date:  1998-05-01       Impact factor: 5.157

6.  Structural insight into the DNA polymerase beta deoxyribose phosphate lyase mechanism.

Authors:  Rajendra Prasad; Vinod K Batra; Xiao-Ping Yang; Joseph M Krahn; Lars C Pedersen; William A Beard; Samuel H Wilson
Journal:  DNA Repair (Amst)       Date:  2005-09-19

7.  Second pathway for completion of human DNA base excision-repair: reconstitution with purified proteins and requirement for DNase IV (FEN1).

Authors:  A Klungland; T Lindahl
Journal:  EMBO J       Date:  1997-06-02       Impact factor: 11.598

8.  Genetic interactions between HNT3/Aprataxin and RAD27/FEN1 suggest parallel pathways for 5' end processing during base excision repair.

Authors:  James M Daley; Thomas E Wilson; Dindial Ramotar
Journal:  DNA Repair (Amst)       Date:  2010-04-15

9.  FEN1 stimulation of DNA polymerase beta mediates an excision step in mammalian long patch base excision repair.

Authors:  R Prasad; G L Dianov; V A Bohr; S H Wilson
Journal:  J Biol Chem       Date:  2000-02-11       Impact factor: 5.157

10.  Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1.

Authors:  John J Reynolds; Sherif F El-Khamisy; Sachin Katyal; Paula Clements; Peter J McKinnon; Keith W Caldecott
Journal:  Mol Cell Biol       Date:  2008-12-22       Impact factor: 4.272
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  25 in total

1.  The DNA Repair Repertoire of Mycobacterium smegmatis FenA Includes the Incision of DNA 5' Flaps and the Removal of 5' Adenylylated Products of Aborted Nick Ligation.

Authors:  Maria Loressa Uson; Shreya Ghosh; Stewart Shuman
Journal:  J Bacteriol       Date:  2017-08-08       Impact factor: 3.490

Review 2.  The role of DNA base excision repair in brain homeostasis and disease.

Authors:  Mansour Akbari; Marya Morevati; Deborah Croteau; Vilhelm A Bohr
Journal:  DNA Repair (Amst)       Date:  2015-05-01

Review 3.  Molecular underpinnings of Aprataxin RNA/DNA deadenylase function and dysfunction in neurological disease.

Authors:  Matthew J Schellenberg; Percy P Tumbale; R Scott Williams
Journal:  Prog Biophys Mol Biol       Date:  2015-01-29       Impact factor: 3.667

Review 4.  Neurological disorders associated with DNA strand-break processing enzymes.

Authors:  Bingcheng Jiang; J N Mark Glover; Michael Weinfeld
Journal:  Mech Ageing Dev       Date:  2016-07-25       Impact factor: 5.432

Review 5.  Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair.

Authors:  Melike Çağlayan; Samuel H Wilson
Journal:  DNA Repair (Amst)       Date:  2015-09-16

Review 6.  Interplay between DNA Polymerases and DNA Ligases: Influence on Substrate Channeling and the Fidelity of DNA Ligation.

Authors:  Melike Çağlayan
Journal:  J Mol Biol       Date:  2019-04-26       Impact factor: 5.469

Review 7.  Reprint of "Oxidant and environmental toxicant-induced effects compromise DNA ligation during base excision DNA repair".

Authors:  Melike Çağlayan; Samuel H Wilson
Journal:  DNA Repair (Amst)       Date:  2015-11-12

8.  Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications.

Authors:  Melike Çağlayan
Journal:  DNA Repair (Amst)       Date:  2020-08-14

9.  The splicing component ISY1 regulates APE1 in base excision repair.

Authors:  Aruna S Jaiswal; Elizabeth A Williamson; Gayathri Srinivasan; Kimi Kong; Carrie L Lomelino; Robert McKenna; Christi Walter; Patrick Sung; Satya Narayan; Robert Hromas
Journal:  DNA Repair (Amst)       Date:  2019-12-13

Review 10.  Eukaryotic Base Excision Repair: New Approaches Shine Light on Mechanism.

Authors:  William A Beard; Julie K Horton; Rajendra Prasad; Samuel H Wilson
Journal:  Annu Rev Biochem       Date:  2019-06-20       Impact factor: 23.643
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