Literature DB >> 24776517

Vancomycin cerebrospinal fluid pharmacokinetics in children with cerebral ventricular shunt infections.

Julie Autmizguine1, Cassie Moran, Daniel Gonzalez, Edmund V Capparelli, P Brian Smith, Gerald A Grant, Daniel K Benjamin, Michael Cohen-Wolkowiez, Kevin M Watt.   

Abstract

This study described the cerebrospinal fluid (CSF) exposure of vancomycin in 8 children prescribed intravenous vancomycin therapy for cerebral ventricular shunt infection. Vancomycin CSF concentrations ranged from 0.06 to 9.13 mg/L and the CSF: plasma ratio ranged from 0 to 0.66. Two of 3 children with a staphylococcal CSF infection had CSF concentrations greater than minimal inhibitory concentration at the end of the dosing interval.

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Year:  2014        PMID： 24776517      PMCID： PMC4209191          DOI： 10.1097/INF.0000000000000385

Source DB:  PubMed          Journal:  Pediatr Infect Dis J        ISSN： 0891-3668            Impact factor:   3.806


  15 in total

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Authors:  Amélie Marsot; Audrey Boulamery; Bernard Bruguerolle; Nicolas Simon
Journal:  Clin Pharmacokinet       Date:  2012-01-01       Impact factor: 6.447

2.  Levels of vancomycin in cerebrospinal fluid of adult patients receiving adjunctive corticosteroids to treat pneumococcal meningitis: a prospective multicenter observational study.

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Journal:  Clin Infect Dis       Date:  2006-12-15       Impact factor: 9.079

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Journal:  Chemotherapy       Date:  1990       Impact factor: 2.544

5.  Pharmacodynamics of vancomycin and other antimicrobials in patients with Staphylococcus aureus lower respiratory tract infections.

Authors:  Pamela A Moise-Broder; Alan Forrest; Mary C Birmingham; Jerome J Schentag
Journal:  Clin Pharmacokinet       Date:  2004       Impact factor: 6.447

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Journal:  J Perinatol       Date:  1996 Sep-Oct       Impact factor: 2.521

7.  Vancomycin disposition and penetration into ventricular fluid of the central nervous system following intravenous therapy in patients with cerebrospinal devices.

Authors:  Laney Jorgenson; Pamela D Reiter; Jane E Freeman; Ken R Winston; Douglas Fish; Lori A McBride; Michael H Handler
Journal:  Pediatr Neurosurg       Date:  2007       Impact factor: 1.162

8.  Phenobarbital and phenytoin in neonatal seizures: metabolism and tissue distribution.

Authors:  M J Painter; C Pippenger; C Wasterlain; M Barmada; W Pitlick; G Carter; S Abern
Journal:  Neurology       Date:  1981-09       Impact factor: 9.910

9.  Vancomycin AUC/MIC ratio and 30-day mortality in patients with Staphylococcus aureus bacteremia.

Authors:  Natasha E Holmes; John D Turnidge; Wendy J Munckhof; J Owen Robinson; Tony M Korman; Matthew V N O'Sullivan; Tara L Anderson; Sally A Roberts; Sanchia J C Warren; Wei Gao; Benjamin P Howden; Paul D R Johnson
Journal:  Antimicrob Agents Chemother       Date:  2013-01-18       Impact factor: 5.191

10.  Risk factors for pediatric ventriculoperitoneal shunt infection and predictors of infectious pathogens.

Authors:  Matthew J McGirt; Aimee Zaas; Herbert E Fuchs; Timothy M George; Keith Kaye; Daniel J Sexton
Journal:  Clin Infect Dis       Date:  2003-03-18       Impact factor: 9.079
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  4 in total

Review 1.  Determining the optimal vancomycin daily dose for pediatrics: a meta-analysis.

Authors:  Geisa Cristina da Silva Alves; Samuel Dutra da Silva; Virginia Paula Frade; Danielle Rodrigues; André de Oliveira Baldoni; Whocely Victor de Castro; Cristina Sanches
Journal:  Eur J Clin Pharmacol       Date:  2017-08-04       Impact factor: 2.953

2.  Effective CSF concentrations achieved with continuous-infusion flucloxacillin in a child.

Authors:  Alison Boast; Jeremy Carr; Nigel Curtis; Andrew J Daley; Amanda Gwee
Journal:  Eur J Clin Pharmacol       Date:  2015-08-26       Impact factor: 2.953

3.  The CSF Vancomycin Concentration in Patients With Post-operative Intracranial Infection Can Be Predicted by the WBCs to Total Cells Ratio and the Serum Trough Concentration.

Authors:  Ming-Chao Fan; Jia-Lin Sun; Jian Sun; Jun-Wei Ma; Nian Wang; Wei Fang
Journal:  Front Neurol       Date:  2022-05-13       Impact factor: 4.086

Review 4.  Advances in Pediatric Pharmacology, Therapeutics, and Toxicology.

Authors:  Laura A Wang; Michael Cohen-Wolkowiez; Daniel Gonzalez
Journal:  Adv Pediatr       Date:  2016-08
  4 in total

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