Won-Beom Jung1, Chi-Woong Mun1, Young-Hoon Kim2, Je Min Park3,4, Byung Dae Lee3,4, Young Min Lee3,4, Eunsoo Moon3,4, Hee Jeong Jeong3,4, Young In Chung5. 1. Department of Biomedical Engineering and FIRST, Inje University, Gimhae, Korea. 2. Department of Psychiatry, Medical School, Haeundae Paik Hospital, Inje University, Busan, Korea. 3. Department of Psychiatry, Pusan National University Hospital, Busan, Korea. 4. Medical Research Institute, Pusan National University Hospital, Busan, Korea. 5. Department of Psychiatry, Pusan National University Yangsan Hospital, Yangsan, Korea.
Abstract
AIMS: An association between white matter hyperintensities (WMH) and cognitive dysfunction has long been recognized. However, subjects with identically appearing WMH on magnetic resonance imaging present with a wide variance in cognitive function ranging from normal cognition to dementia. The aim of this study was to compare cortical atrophy and integrity of white matter of patients with subcortical vascular dementia of Binswanger type (SVaD-BT) with those of the normal cognition group with WMH (ncWMH). METHODS: Eleven patients with SVaD-BT and 11 age-, sex-, education- and grade of WMH-matched ncWMH underwent magnetic resonance imaging, including 3-D volumetric images for cortical atrophy and diffusion tensor imaging for integrity of white matter. RESULTS: Compared to ncWMH, SVaD-BT patients showed cortical atrophies in frontal (i.e. frontal pole, precentral gyrus and frontal medial cortex) and occipital areas (i.e. lingual gyrus) followed by atrophies in temporal (i.e. fusiform cortex and middle temporal gyrus) areas. Along with cortical atrophies, reduced integrity with low fractional anisotropy and high mean diffusivity values in genu and splenium of the corpus callosum were detected in SVaD-BT patients. CONCLUSIONS: Our findings suggest that cognitive decline from ncWMH to SVaD-BT may be associated with cortical atrophy and reduced integrity of white matter.
AIMS: An association between white matter hyperintensities (WMH) and cognitive dysfunction has long been recognized. However, subjects with identically appearing WMH on magnetic resonance imaging present with a wide variance in cognitive function ranging from normal cognition to dementia. The aim of this study was to compare cortical atrophy and integrity of white matter of patients with subcortical vascular dementia of Binswanger type (SVaD-BT) with those of the normal cognition group with WMH (ncWMH). METHODS: Eleven patients with SVaD-BT and 11 age-, sex-, education- and grade of WMH-matched ncWMH underwent magnetic resonance imaging, including 3-D volumetric images for cortical atrophy and diffusion tensor imaging for integrity of white matter. RESULTS: Compared to ncWMH, SVaD-BTpatients showed cortical atrophies in frontal (i.e. frontal pole, precentral gyrus and frontal medial cortex) and occipital areas (i.e. lingual gyrus) followed by atrophies in temporal (i.e. fusiform cortex and middle temporal gyrus) areas. Along with cortical atrophies, reduced integrity with low fractional anisotropy and high mean diffusivity values in genu and splenium of the corpus callosum were detected in SVaD-BTpatients. CONCLUSIONS: Our findings suggest that cognitive decline from ncWMH to SVaD-BT may be associated with cortical atrophy and reduced integrity of white matter.
Keywords:
cortical atrophy; diffusion tensor imaging; integrity of white matter; magnetic resonance imaging; subcortical vascular dementia of Binswanger type
Authors: Won Hwa Kim; Annie M Racine; Nagesh Adluru; Seong Jae Hwang; Kaj Blennow; Henrik Zetterberg; Cynthia M Carlsson; Sanjay Asthana; Rebecca L Koscik; Sterling C Johnson; Barbara B Bendlin; Vikas Singh Journal: Neuroimage Clin Date: 2018-10-23 Impact factor: 4.881
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