Literature DB >> 24773141

Bis(imidazolidine)pyridine-NiCl2 Catalyst for nitro-Mannich reaction of isatin-derived N-Boc ketimines: asymmetric synthesis of chiral 3-substituted 3-amino-2-oxindoles.

Takayoshi Arai1, Eri Matsumura, Hyuma Masu.   

Abstract

An (S,S)-diphenyldiamine-derived bis(imidazolidine)pyridine (PyBidine)-NiCl2 complex catalyzed the nitro-Mannich reaction of isatin-derived N-Boc ketimines to construct a chiral quaternary aminocarbon center at the C3 position of oxindoles in yields of up to 99% with 95% ee.

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Year:  2014        PMID： 24773141     DOI： 10.1021/ol501085y

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  2 in total

1.  Catalytic enantioselective Henry reaction of α-keto esters, 2-acylpyridines and 2-acylpyridine N-oxides.

Authors:  Feilong He; Guanghui Chen; Junxia Yang; Guojuan Liang; Ping Deng; Yan Xiong; Hui Zhou
Journal:  RSC Adv       Date:  2018-03-05       Impact factor: 4.036

2.  Guanidine-Amide-Catalyzed Aza-Henry Reaction of Isatin-Derived Ketimines: Origin of Selectivity and New Catalyst Design.

Authors:  Jiajia He; Dianyong Tang; Changwei Hu; Zhishan Su
Journal:  Molecules       Date:  2021-03-31       Impact factor: 4.411
  2 in total

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