Literature DB >> 24769077

O-GlcNAc signaling in cancer metabolism and epigenetics.

Jay Prakash Singh1, Kaisi Zhang2, Jing Wu3, Xiaoyong Yang4.   

Abstract

The covalent attachment of β-D-N-acetylglucosamine monosaccharides (O-GlcNAc) to serine/threonine residues of nuclear and cytoplasmic proteins is a major regulatory mechanism in cell physiology. Aberrant O-GlcNAc modification of signaling proteins, metabolic enzymes, and transcriptional and epigenetic regulators has been implicated in cancer. Relentless growth of cancer cells requires metabolic reprogramming that is intertwined with changes in the epigenetic landscape. This review highlights the emerging role of protein O-GlcNAcylation at the interface of cancer metabolism and epigenetics.
Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Cancer metabolism; Epigenetics; O-GlcNAc; Posttranslational modifications

Mesh：

Substances：

Year:  2014        PMID： 24769077      PMCID： PMC4208982          DOI： 10.1016/j.canlet.2014.04.014

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  133 in total

1.  On respiratory impairment in cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-08-10       Impact factor: 47.728

2.  On the origin of cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

3.  Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway.

Authors:  Salima Daou; Nazar Mashtalir; Ian Hammond-Martel; Helen Pak; Helen Yu; Guangchao Sui; Jodi L Vogel; Thomas M Kristie; El Bachir Affar
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-01       Impact factor: 11.205

4.  Beta-N-acetylglucosamine (O-GlcNAc) is part of the histone code.

Authors:  Kaoru Sakabe; Zihao Wang; Gerald W Hart
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-02       Impact factor: 11.205

5.  β-N-Acetylglucosamine (O-GlcNAc) is a novel regulator of mitosis-specific phosphorylations on histone H3.

Authors:  Jerry J Fong; Brenda L Nguyen; Robert Bridger; Estela E Medrano; Lance Wells; Shujuan Pan; Richard N Sifers
Journal:  J Biol Chem       Date:  2012-02-27       Impact factor: 5.157

6.  Differential regulation of the ten-eleven translocation (TET) family of dioxygenases by O-linked β-N-acetylglucosamine transferase (OGT).

Authors:  Qiao Zhang; Xiaoguang Liu; Wenqi Gao; Pishun Li; Jingli Hou; Jiwen Li; Jiemin Wong
Journal:  J Biol Chem       Date:  2014-01-06       Impact factor: 5.157

7.  Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases.

Authors:  Claudia Crosio; Gian Maria Fimia; Romain Loury; Masashi Kimura; Yukio Okano; Hongyi Zhou; Subrata Sen; C David Allis; Paolo Sassone-Corsi
Journal:  Mol Cell Biol       Date:  2002-02       Impact factor: 4.272

8.  Calcium/calmodulin-dependent kinase II plays an important role in prostate cancer cell survival.

Authors:  Oskar W Rokhlin; Agshin F Taghiyev; K Ulrich Bayer; David Bumcrot; Victor E Koteliansk; Rebecca A Glover; Michael B Cohen
Journal:  Cancer Biol Ther       Date:  2007-02-05       Impact factor: 4.742

9.  Glycosylation of the c-Myc transactivation domain.

Authors:  T Y Chou; C V Dang; G W Hart
Journal:  Proc Natl Acad Sci U S A       Date:  1995-05-09       Impact factor: 11.205

10.  Ten-eleven translocation 1 (Tet1) is regulated by O-linked N-acetylglucosamine transferase (Ogt) for target gene repression in mouse embryonic stem cells.

Authors:  Feng-Tao Shi; Hyeung Kim; Weisi Lu; Quanyuan He; Dan Liu; Margaret A Goodell; Ma Wan; Zhou Songyang
Journal:  J Biol Chem       Date:  2013-05-31       Impact factor: 5.157
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  60 in total

1.  Human and rodent temporal lobe epilepsy is characterized by changes in O-GlcNAc homeostasis that can be reversed to dampen epileptiform activity.

Authors:  Richard G Sánchez; R Ryley Parrish; Megan Rich; William M Webb; Roxanne M Lockhart; Kazuhito Nakao; Lara Ianov; Susan C Buckingham; Devin R Broadwater; Alistair Jenkins; Nihal C de Lanerolle; Mark Cunningham; Tore Eid; Kristen Riley; Farah D Lubin
Journal:  Neurobiol Dis       Date:  2019-01-06       Impact factor: 5.996

2.  Structures of human O-GlcNAcase and its complexes reveal a new substrate recognition mode.

Authors:  Baobin Li; Hao Li; Lei Lu; Jiaoyang Jiang
Journal:  Nat Struct Mol Biol       Date:  2017-03-20       Impact factor: 15.369

Review 3.  Chemical and Biochemical Strategies To Explore the Substrate Recognition of O-GlcNAc-Cycling Enzymes.

Authors:  Chia-Wei Hu; Matthew Worth; Hao Li; Jiaoyang Jiang
Journal:  Chembiochem       Date:  2018-11-12       Impact factor: 3.164

4.  Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.

Authors:  Nathaniel L Elsen; Sangita B Patel; Rachael E Ford; Dawn L Hall; Fred Hess; Hari Kandula; Maria Kornienko; John Reid; Harold Selnick; Jennifer M Shipman; Sujata Sharma; Kevin J Lumb; Stephen M Soisson; Daniel J Klein
Journal:  Nat Chem Biol       Date:  2017-03-27       Impact factor: 15.040

Review 5.  The regulatory roles of O-GlcNAcylation in mitochondrial homeostasis and metabolic syndrome.

Authors:  Lin Zhao; Zhihui Feng; Xiaoyong Yang; Jiankang Liu
Journal:  Free Radic Res       Date:  2016-10-19

6.  O-Linked N-Acetylglucosamine (O-GlcNAc) Expression Levels Epigenetically Regulate Colon Cancer Tumorigenesis by Affecting the Cancer Stem Cell Compartment via Modulating Expression of Transcriptional Factor MYBL1.

Authors:  Huabei Guo; Bing Zhang; Alison V Nairn; Tamas Nagy; Kelley W Moremen; Phillip Buckhaults; Michael Pierce
Journal:  J Biol Chem       Date:  2017-01-17       Impact factor: 5.157

7.  O-GlcNAcylation regulates integrin-mediated cell adhesion and migration via formation of focal adhesion complexes.

Authors:  Zhiwei Xu; Tomoya Isaji; Tomohiko Fukuda; Yuqin Wang; Jianguo Gu
Journal:  J Biol Chem       Date:  2018-12-26       Impact factor: 5.157

Review 8.  O-GlcNAc in cancer: An Oncometabolism-fueled vicious cycle.

Authors:  John A Hanover; Weiping Chen; Michelle R Bond
Journal:  J Bioenerg Biomembr       Date:  2018-03-29       Impact factor: 2.945

9.  A complex containing the O-GlcNAc transferase OGT-1 and the ubiquitin ligase EEL-1 regulates GABA neuron function.

Authors:  Andrew C Giles; Muriel Desbois; Karla J Opperman; Rubens Tavora; Marissa J Maroni; Brock Grill
Journal:  J Biol Chem       Date:  2019-03-11       Impact factor: 5.157

10.  Abnormal O-GlcNAcylation of Pax3 Occurring from Hyperglycemia-Induced Neural Tube Defects Is Ameliorated by Carnosine But Not Folic Acid in Chicken Embryos.

Authors:  Rui-Rong Tan; Yi-Fang Li; Shi-Jie Zhang; Wen-Shan Huang; Bun Tsoi; Dan Hu; Xin Wan; Xuesong Yang; Qi Wang; Hiroshi Kurihara; Rong-Rong He
Journal:  Mol Neurobiol       Date:  2016-01-06       Impact factor: 5.590
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