PURPOSE: To assess retinal vessel oxygen saturation and retinal vessel diameter in retinitis pigmentosa. METHODS: A retinal oximeter (Oxymap ehf., Reykjavik, Iceland) was used to measure retinal vessel oxygen saturation and vessel diameter in ten patients with retinitis pigmentosa (RP) (mean age 49 years, range 23-71 years). Results were compared with age- and gender-matched healthy individuals. All patients had advanced stage of the disease with visual fields restricted to the macular region. RESULTS: Oxygen saturation in retinal venules was 58.0 ± 6.2% in patients with RP and 53.4 ± 4.8% in healthy subjects (p = 0.017). Oxygen saturation in retinal arterioles was not significantly different between groups (p = 0.65). The mean diameter of retinal arterioles was 8.9 ± 1.6 pixels in patients with RP and 11.4 ± 1.2 in healthy controls (p < 0.0001). The corresponding diameters for venules were 10.1 ± 1.2 (RP) and 15.3 ± 1.7 (healthy, p < 0.0001). CONCLUSIONS: Increased venous saturation and decreased retinal vessel diameter suggest decreased oxygen delivery from the retinal circulation in retinitis pigmentosa. This is probably secondary to tissue atrophy and reduced oxygen consumption.
PURPOSE: To assess retinal vessel oxygen saturation and retinal vessel diameter in retinitis pigmentosa. METHODS: A retinal oximeter (Oxymap ehf., Reykjavik, Iceland) was used to measure retinal vessel oxygen saturation and vessel diameter in ten patients with retinitis pigmentosa (RP) (mean age 49 years, range 23-71 years). Results were compared with age- and gender-matched healthy individuals. All patients had advanced stage of the disease with visual fields restricted to the macular region. RESULTS:Oxygen saturation in retinal venules was 58.0 ± 6.2% in patients with RP and 53.4 ± 4.8% in healthy subjects (p = 0.017). Oxygen saturation in retinal arterioles was not significantly different between groups (p = 0.65). The mean diameter of retinal arterioles was 8.9 ± 1.6 pixels in patients with RP and 11.4 ± 1.2 in healthy controls (p < 0.0001). The corresponding diameters for venules were 10.1 ± 1.2 (RP) and 15.3 ± 1.7 (healthy, p < 0.0001). CONCLUSIONS: Increased venous saturation and decreased retinal vessel diameter suggest decreased oxygen delivery from the retinal circulation in retinitis pigmentosa. This is probably secondary to tissue atrophy and reduced oxygen consumption.
Authors: Margarita G Todorova; Hendrik P N Scholl; Maria Della Volpe Waizel Journal: Graefes Arch Clin Exp Ophthalmol Date: 2020-09-10 Impact factor: 3.117
Authors: Rossiana I Bojinova; Daniel F Schorderet; Christophe Valmaggia; Cengiz Türksever; Andreas Schoetzau; Margarita G Todorova Journal: Eye (Lond) Date: 2018-03-06 Impact factor: 3.775
Authors: Maria Della Volpe-Waizel; Hanna Camenzind Zuche; Ursula Müller; Annekatrin Rickmann; Hendrik P N Scholl; Margarita G Todorova Journal: Graefes Arch Clin Exp Ophthalmol Date: 2019-11-12 Impact factor: 3.117
Authors: Young Ju Lew; Nicholas Rinella; Jia Qin; Joanna Chiang; Anthony T Moore; Travis C Porco; Austin Roorda; Jacque L Duncan Journal: Am J Ophthalmol Date: 2017-11-16 Impact factor: 5.258