Literature DB >> 2476705

Frequent amplification of the bcl-1 locus in head and neck squamous cell carcinomas.

J R Berenson1, J Yang, R A Mickel.   

Abstract

The bcl-1 locus on chromosome 11 at band q13 has been shown to be rearranged in some chronic B lymphoid malignancies with the t(11;14)(q13;q32). Chromosome 11 abnormalities also occur in squamous cell carcinomas including tumors from the head and neck region. In this investigation, we analysed the arrangement, copy number and expression of this locus in 23 fresh head and neck cancers and six established head and neck squamous cell carcinoma cell lines. Bcl-1 was found to be amplified two- to 10-fold in eight fresh tumors and two cell lines, UM-SCC-8 and UM-SCC-22A. Moreover, amplification was more frequently observed in poorly differentiated fresh tumors. None of the fresh tumors or cell lines showed rearrangement of bcl-1. In addition, these tumors and cell lines did not contain amplification of the c-myc or Ha-ras oncogenes.

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Year:  1989        PMID： 2476705

Source DB:  PubMed          Journal:  Oncogene        ISSN： 0950-9232            Impact factor:   9.867


  28 in total

1.  New gene in the homologous human 11q13-q14 and mouse 7F chromosomal regions.

Authors:  V Ollendorff; P Szepetowski; M G Mattei; P Gaudray; D Birnbaum
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

2.  Amplification and overexpression of the cyclin D1 gene in head and neck squamous cell carcinoma.

Authors:  X Wang; Z P Pavelic; Y Q Li; L Wang; L Gleich; K Radack; J L Gluckman; P J Stambrook
Journal:  Clin Mol Pathol       Date:  1995-10

3.  A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci.

Authors:  C W Richard; D A Withers; T C Meeker; S Maurer; G A Evans; R M Myers; D R Cox
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

4.  Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1.

Authors:  Nishant Agrawal; Mitchell J Frederick; Curtis R Pickering; Chetan Bettegowda; Kyle Chang; Ryan J Li; Carole Fakhry; Tong-Xin Xie; Jiexin Zhang; Jing Wang; Nianxiang Zhang; Adel K El-Naggar; Samar A Jasser; John N Weinstein; Lisa Treviño; Jennifer A Drummond; Donna M Muzny; Yuanqing Wu; Laura D Wood; Ralph H Hruban; William H Westra; Wayne M Koch; Joseph A Califano; Richard A Gibbs; David Sidransky; Bert Vogelstein; Victor E Velculescu; Nickolas Papadopoulos; David A Wheeler; Kenneth W Kinzler; Jeffrey N Myers
Journal:  Science       Date:  2011-07-28       Impact factor: 47.728

Review 5.  Molecular pathogenesis of head and neck squamous cell carcinoma.

Authors:  David Hardisson
Journal:  Eur Arch Otorhinolaryngol       Date:  2003-05-08       Impact factor: 2.503

Review 6.  [Surgical treatment options for squamous cell carcinoma of the oral cavity].

Authors:  Michael Rasse
Journal:  Wien Med Wochenschr       Date:  2008

7.  p53 alterations in human squamous cell carcinomas and carcinoma cell lines.

Authors:  J Caamano; S Y Zhang; E A Rosvold; B Bauer; A J Klein-Szanto
Journal:  Am J Pathol       Date:  1993-04       Impact factor: 4.307

Review 8.  Molecular and cellular biomarkers for field cancerization and multistep process in head and neck tumorigenesis.

Authors:  V A Papadimitrakopoulou; D M Shin; W K Hong
Journal:  Cancer Metastasis Rev       Date:  1996-03       Impact factor: 9.264

Review 9.  Retinoid chemoprevention trials: cyclin D1 in the crosshairs.

Authors:  Sarah J Freemantle; Yongli Guo; Ethan Dmitrovsky
Journal:  Cancer Prev Res (Phila)       Date:  2009-01

10.  Immunohistochemistry of cyclin D3 in pulmonary carcinomas.

Authors:  H Usuda; T Saito; I Emura; M Naito
Journal:  Virchows Arch       Date:  1996-06       Impact factor: 4.064
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