| Literature DB >> 24767047 |
Miguel Vázquez-Velasco1, Laura González-Torres1, Patricia López-Gasco2, Sara Bastida1, Juana Benedí2, María Isabel Sánchez-Reus3, María José González-Muñoz4, Francisco J Sánchez-Muniz5.
Abstract
The effect of high-fat squid-surimi diets enriched in glucomannan or glucomannan-spirulina on lipemia, liver glutathione status, antioxidant enzymes and inflammation biomarkers was determined in Zucker Fa/Fa rats. Groups of eight rats each received for 7weeks the squid-surimi control (C), glucomannan-enriched squid-surimi (G) and glucomannan-spirulina enriched squid-surimi (GS). Liver weight, cytochrome P450 7A1 expression and cholesterolemia were decreased in G and GS vs. C, improving glutathione red-ox index (p<0.05). G also showed increased glutathione reductase (GR) levels vs. C, but reduced the endothelial (eNOS) and increased the inducible nitric oxide synthase (iNOS) and tumor necrosis factor-alpha (TNF-α) levels (p<0.05). The GS diet improved superoxide dismutase, catalase, glutathione peroxidase and GR activities and eNOS, iNOS and TNF-α levels (p<0.05). The glucomannan enriched surimi-diet induced hypocholesterolemic, antioxidant and proinflammatory effects, while the addition of 3g/kg spirulina kept those hypocholesterolemic and antioxidant effects but reduced the inflammation observed.Entities:
Keywords: Antioxidants; Glucomannan; Glutathione system; Inflammation; Spirulina; Squid-surimi
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Year: 2014 PMID： 24767047 DOI： 10.1016/j.foodchem.2014.03.015
Source DB: PubMed Journal: Food Chem ISSN： 0308-8146 Impact factor: 7.514