| Literature DB >> 24766844 |
Abstract
Controlled proteolysis is key to bacterial viability. In this issue of Chemistry & Biology, Gavrish and colleagues characterize a natural product, lassomycin, targeting the Mycobacterium tuberculosis caseinolytic (Clp) protease. Unusually, lassomycin activates ClpC1, inducing ATPase activity and decoupling it from proteolysis.Entities:
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Year: 2014 PMID： 24766844 DOI： 10.1016/j.chembiol.2014.04.002
Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521