| Literature DB >> 2476662 |
T Tamura1, A Aoyama, T Inoue, M Miura, H Okano, K Mikoshiba.
Abstract
The mouse myelin basic protein promoter was transcribed in brain nuclear extracts. The distal promoter region from -253 to -54 directed preferential transcription in brain extracts, whereas the same region repressed transcription activity in liver extracts. Stimulation of transcription was observed when the distal region was located only in a native orientation. The proximal region downstream from -53 alone still directed preferential transcription. It is suggested that cooperative function by the two promoter regions may be required for higher specificity.Entities:
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Year: 1989 PMID: 2476662 PMCID: PMC362786 DOI: 10.1128/mcb.9.7.3122-3126.1989
Source DB: PubMed Journal: Mol Cell Biol ISSN: 0270-7306 Impact factor: 4.272