Literature DB >> 24763985

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect.

Bogdan Draghici1, Daniela Vullo, Suleyman Akocak, Ellen A Walker, Claudiu T Supuran, Marc A Ilies.   

Abstract

A series of ethylene bis-imidazoles was synthesized via a novel microwave-mediated synthesis. Biological testing on eight isozymes of carbonic anhydrase (CA) present in the human brain revealed compounds with nanomolar potency against CA VA and CA VII, also displaying excellent selectivity against other CA isozymes present in this organ.

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Year:  2014        PMID： 24763985     DOI： 10.1039/c4cc02346c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

Review 1.  Carbonic anhydrases as disease markers.

Authors:  Sabina Zamanova; Ahmed M Shabana; Utpal K Mondal; Marc A Ilies
Journal:  Expert Opin Ther Pat       Date:  2019-06-17       Impact factor: 6.674

2.  Crystal Structure of Carbonic Anhydrase II in Complex with an Activating Ligand: Implications in Neuronal Function.

Authors:  Avni Bhatt; Utpal K Mondal; Claudiu T Supuran; Marc A Ilies; Robert McKenna
Journal:  Mol Neurobiol       Date:  2018-02-08       Impact factor: 5.590

3.  Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators.

Authors:  Adriano Mollica; Giorgia Macedonio; Azzurra Stefanucci; Simone Carradori; Atilla Akdemir; Andrea Angeli; Claudiu T Supuran
Journal:  Molecules       Date:  2017-12-09       Impact factor: 4.411

Review 4.  Amine- and Amino Acid-Based Compounds as Carbonic Anhydrase Activators.

Authors:  Andrea Angeli; Emanuela Berrino; Simone Carradori; Claudiu T Supuran; Marzia Cirri; Fabrizio Carta; Gabriele Costantino
Journal:  Molecules       Date:  2021-12-02       Impact factor: 4.411

Review 5.  Carbonic Anhydrases as Potential Targets Against Neurovascular Unit Dysfunction in Alzheimer's Disease and Stroke.

Authors:  Nicole Lemon; Elisa Canepa; Marc A Ilies; Silvia Fossati
Journal:  Front Aging Neurosci       Date:  2021-11-16       Impact factor: 5.750

6.  Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors.

Authors:  Mehmet Onyılmaz; Murat Koca; Alessandro Bonardi; Mustafa Degirmenci; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2022-12       Impact factor: 5.051

7.  Synthesis and biological evaluation of histamine Schiff bases as carbonic anhydrase I, II, IV, VII, and IX activators.

Authors:  Suleyman Akocak; Nabih Lolak; Daniela Vullo; Mustafa Durgun; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2017-12       Impact factor: 5.051

8.  Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors.

Authors:  Suleyman Akocak; Nabih Lolak; Silvia Bua; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051

9.  Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA.

Authors:  Akram A Da'dara; Andrea Angeli; Marta Ferraroni; Claudiu T Supuran; Patrick J Skelly
Journal:  Commun Biol       Date:  2019-09-05

10.  Activation of carbonic anhydrases from human brain by amino alcohol oxime ethers: towards human carbonic anhydrase VII selective activators.

Authors:  Alessio Nocentini; Doretta Cuffaro; Lidia Ciccone; Elisabetta Orlandini; Susanna Nencetti; Elisa Nuti; Armando Rossello; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2021-12       Impact factor: 5.051
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