| Literature DB >> 24759934 |
Fabio Sterpone1, Simone Melchionna, Pierre Tuffery, Samuela Pasquali, Normand Mousseau, Tristan Cragnolini, Yassmine Chebaro, Jean-Francois St-Pierre, Maria Kalimeri, Alessandro Barducci, Yoann Laurin, Alex Tek, Marc Baaden, Phuong Hoang Nguyen, Philippe Derreumaux.
Abstract
The OPEP coarse-grained protein model has been applied to a wide range of applications since its first release 15 years ago. The model, which combines energetic and structural accuracy and chemical specificity, allows the study of single protein properties, DNA-RNA complexes, amyloid fibril formation and protein suspensions in a crowded environment. Here we first review the current state of the model and the most exciting applications using advanced conformational sampling methods. We then present the current limitations and a perspective on the ongoing developments.Entities:
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Year: 2014 PMID： 24759934 PMCID： PMC4426487 DOI： 10.1039/c4cs00048j
Source DB: PubMed Journal: Chem Soc Rev ISSN： 0306-0012 Impact factor: 54.564