Chunying Wang1, Lizhi Li2, Boxiong Shen3, Hui Jiang4, Lan Yuan5, Dongping Shi6, Junfeng Zhu7, Xuan Guo8, Hua Li9. 1. Department of Anesthesiology, Shanghai Huangpu Hospital Shanghai 200002, China. 2. Department of Anesthesiology, Shanghai Pudong New Area People's Hospital Shanghai 201200, China. 3. No. 3 People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 201999, China. 4. Department of Anesthesiology, Shanghai Qingpu District Center Hospital Shanghai 201700, China. 5. Department of Anesthesiology, Shanghai Shuguang Hospital Shanghai 200021, China. 6. Department of Anesthesiology, Shanghai Jiading District Center Hospital Shanghai 201800, China. 7. Department of Anesthesiology, Shanghai Jinshan District Center Hospital Shanghai 201500, China. 8. Department of Anesthesiology, Shanghai Yangpu District Center Hospital Shanghai 200090, China. 9. Department of Anesthesiology, Shanghai Dahua Hospital of Shanghai Xuhui District Hospital Shanghai 200237, China.
Abstract
OBJECTIVE: The postoperative PCIA effects of dezocine in elderly patients were determined using a large multicenter randomized double-blind prospective study. METHODS: A total of 279 patients were randomized into four groups: (1) Control group (C): 2 μg/kg sufentanil plus 10 mg metoclopramide. (2) Dezocine group 1 (D1): 1 μg/kg sufentanil plus 0.1 mg/kg dezocine plus 10 mg metoclopramide. (3) Dezocine group 2 (D2): 1 μg/kg sufentanil plus 0.2 mg/kg dezocine plus 10 mg metoclopramide. (4) Dezocine group 3 (D3): 1 μg/kg sufentanil plus 0.3 mg/kg dezocine plus 10 mg metoclopramide. The index during operation including MAP, HR, SpO2, ETCO2, CVP, and BIS were determined. Analgesia effects including HR, MAP, RR, SpO2, pressing times of PCA demand, pressing times of PCR delivery, total amount of drug, additional sufentanil, VAS at rest and during moving, Ramsay sedation score, and BCS were repeated measured 1 h, 3 h, 6 h, 24 h, and 48 h after surgery. Overall satisfaction index and the side-effects including nausea, urinary retention, skin pruritus and respiratory depression were evaluated 1 h, 3 h, 6 h, 24 h, and 48 h after surgery. RESULTS:Dezocine combining with sufentanil is complement for sufentanil in PCIA at least in its analgesia effects after surgery. Dezocine at a dosage of 0.1 mg/kg or 0.2 mg/kg combining with sufentanil (1 μg/kg) has limited side effects as sufentanil (2 μg/kg) in PCIA. Sufentanil (1 μg/kg) combining Dezocine at a dosage of 0.1 mg/kg or 0.2 mg/kg is better than combining Dezocine at a dosage of 0.3 mg/kg in PCIA at least in Overall satisfaction index. CONCLUSION:Dezocine combining with sufentanil is a complement drug for sufentanil in PCIA. Considering the side effects and overall satisfaction index, 0.1 mg/kg seems to be an ideal dosage for Dezocine using in the postoperative PCIA in elderly patients.
RCT Entities:
OBJECTIVE: The postoperative PCIA effects of dezocine in elderly patients were determined using a large multicenter randomized double-blind prospective study. METHODS: A total of 279 patients were randomized into four groups: (1) Control group (C): 2 μg/kg sufentanil plus 10 mg metoclopramide. (2) Dezocine group 1 (D1): 1 μg/kg sufentanil plus 0.1 mg/kg dezocine plus 10 mg metoclopramide. (3) Dezocine group 2 (D2): 1 μg/kg sufentanil plus 0.2 mg/kg dezocine plus 10 mg metoclopramide. (4) Dezocine group 3 (D3): 1 μg/kg sufentanil plus 0.3 mg/kg dezocine plus 10 mg metoclopramide. The index during operation including MAP, HR, SpO2, ETCO2, CVP, and BIS were determined. Analgesia effects including HR, MAP, RR, SpO2, pressing times of PCA demand, pressing times of PCR delivery, total amount of drug, additional sufentanil, VAS at rest and during moving, Ramsay sedation score, and BCS were repeated measured 1 h, 3 h, 6 h, 24 h, and 48 h after surgery. Overall satisfaction index and the side-effects including nausea, urinary retention, skin pruritus and respiratory depression were evaluated 1 h, 3 h, 6 h, 24 h, and 48 h after surgery. RESULTS:Dezocine combining with sufentanil is complement for sufentanil in PCIA at least in its analgesia effects after surgery. Dezocine at a dosage of 0.1 mg/kg or 0.2 mg/kg combining with sufentanil (1 μg/kg) has limited side effects as sufentanil (2 μg/kg) in PCIA. Sufentanil (1 μg/kg) combining Dezocine at a dosage of 0.1 mg/kg or 0.2 mg/kg is better than combining Dezocine at a dosage of 0.3 mg/kg in PCIA at least in Overall satisfaction index. CONCLUSION:Dezocine combining with sufentanil is a complement drug for sufentanil in PCIA. Considering the side effects and overall satisfaction index, 0.1 mg/kg seems to be an ideal dosage for Dezocine using in the postoperative PCIA in elderly patients.
Authors: Harvey A Whiteford; Louisa Degenhardt; Jürgen Rehm; Amanda J Baxter; Alize J Ferrari; Holly E Erskine; Fiona J Charlson; Rosana E Norman; Abraham D Flaxman; Nicole Johns; Roy Burstein; Christopher J L Murray; Theo Vos Journal: Lancet Date: 2013-08-29 Impact factor: 79.321
Authors: Man Feng; Qinli Feng; Yujie Chen; Ge Liu; Zhuanglei Gao; Juan Xiao; Chang Feng Journal: Drug Des Devel Ther Date: 2021-05-27 Impact factor: 4.162