Literature DB >> 24747576

The age and genomic integrity of neurons after cortical stroke in humans.

Hagen B Huttner1, Olaf Bergmann2, Mehran Salehpour3, Attila Rácz4, Jemal Tatarishvili5, Emma Lindgren6, Tamás Csonka7, László Csiba8, Tibor Hortobágyi7, Gábor Méhes7, Elisabet Englund9, Beata Werne Solnestam10, Sofia Zdunek6, Christian Scharenberg11, Lena Ström6, Patrik Ståhl6, Benjamin Sigurgeirsson10, Andreas Dahl12, Stefan Schwab4, Göran Possnert3, Samuel Bernard13, Zaal Kokaia5, Olle Lindvall5, Joakim Lundeberg10, Jonas Frisén6.   

Abstract

It has been unclear whether ischemic stroke induces neurogenesis or neuronal DNA rearrangements in the human neocortex. Using immunohistochemistry; transcriptome, genome and ploidy analyses; and determination of nuclear bomb test-derived (14)C concentration in neuronal DNA, we found neither to be the case. A large proportion of cortical neurons displayed DNA fragmentation and DNA repair a short time after stroke, whereas neurons at chronic stages after stroke showed DNA integrity, demonstrating the relevance of an intact genome for survival.

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Year:  2014        PMID： 24747576     DOI： 10.1038/nn.3706

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  22 in total

1.  Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.

Authors:  Tobias Rausch; David T W Jones; Marc Zapatka; Adrian M Stütz; Thomas Zichner; Joachim Weischenfeldt; Natalie Jäger; Marc Remke; David Shih; Paul A Northcott; Elke Pfaff; Jelena Tica; Qi Wang; Luca Massimi; Hendrik Witt; Sebastian Bender; Sabrina Pleier; Huriye Cin; Cynthia Hawkins; Christian Beck; Andreas von Deimling; Volkmar Hans; Benedikt Brors; Roland Eils; Wolfram Scheurlen; Jonathon Blake; Vladimir Benes; Andreas E Kulozik; Olaf Witt; Dianna Martin; Cindy Zhang; Rinnat Porat; Diana M Merino; Jonathan Wasserman; Nada Jabado; Adam Fontebasso; Lars Bullinger; Frank G Rücker; Konstanze Döhner; Hartmut Döhner; Jan Koster; Jan J Molenaar; Rogier Versteeg; Marcel Kool; Uri Tabori; David Malkin; Andrey Korshunov; Michael D Taylor; Peter Lichter; Stefan M Pfister; Jan O Korbel
Journal:  Cell       Date:  2012-01-20       Impact factor: 41.582

2.  Ischemic preconditioning in the rat brain enhances the repair of endogenous oxidative DNA damage by activating the base-excision repair pathway.

Authors:  Wenjin Li; Yumin Luo; Feng Zhang; Armando P Signore; Glenn T Gobbel; Roger P Simon; Jun Chen
Journal:  J Cereb Blood Flow Metab       Date:  2006-02       Impact factor: 6.200

3.  Dynamics of hippocampal neurogenesis in adult humans.

Authors:  Kirsty L Spalding; Olaf Bergmann; Kanar Alkass; Samuel Bernard; Mehran Salehpour; Hagen B Huttner; Emil Boström; Isabelle Westerlund; Celine Vial; Bruce A Buchholz; Göran Possnert; Deborah C Mash; Henrik Druid; Jonas Frisén
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

4.  Long-lasting regeneration after ischemia in the cerebral cortex.

Authors:  Ronen R Leker; Frank Soldner; Ivan Velasco; Denise K Gavin; Andreas Androutsellis-Theotokis; Ronald D G McKay
Journal:  Stroke       Date:  2006-11-22       Impact factor: 7.914

5.  Increased subventricular zone-derived cortical neurogenesis after ischemic lesion.

Authors:  Maria Kreuzberg; Evgeny Kanov; Oleg Timofeev; Markus Schwaninger; Hannah Monyer; Konstantin Khodosevich
Journal:  Exp Neurol       Date:  2010-08-14       Impact factor: 5.330

6.  Evidence for cardiomyocyte renewal in humans.

Authors:  Olaf Bergmann; Ratan D Bhardwaj; Samuel Bernard; Sofia Zdunek; Fanie Barnabé-Heider; Stuart Walsh; Joel Zupicich; Kanar Alkass; Bruce A Buchholz; Henrik Druid; Stefan Jovinge; Jonas Frisén
Journal:  Science       Date:  2009-04-03       Impact factor: 47.728

7.  Ischemia-induced neurogenesis of neocortical layer 1 progenitor cells.

Authors:  Koji Ohira; Takahiro Furuta; Hiroyuki Hioki; Kouichi C Nakamura; Eriko Kuramoto; Yasuyo Tanaka; Nobuo Funatsu; Keiko Shimizu; Takao Oishi; Motoharu Hayashi; Tsuyoshi Miyakawa; Takeshi Kaneko; Shun Nakamura
Journal:  Nat Neurosci       Date:  2009-12-27       Impact factor: 24.884

8.  Large scale library generation for high throughput sequencing.

Authors:  Erik Borgström; Sverker Lundin; Joakim Lundeberg
Journal:  PLoS One       Date:  2011-04-27       Impact factor: 3.240

9.  Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.

Authors:  Elsa Suberbielle; Pascal E Sanchez; Alexxai V Kravitz; Xin Wang; Kaitlyn Ho; Kirsten Eilertson; Nino Devidze; Anatol C Kreitzer; Lennart Mucke
Journal:  Nat Neurosci       Date:  2013-03-24       Impact factor: 24.884

10.  TopHat: discovering splice junctions with RNA-Seq.

Authors:  Cole Trapnell; Lior Pachter; Steven L Salzberg
Journal:  Bioinformatics       Date:  2009-03-16       Impact factor: 6.937
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  47 in total

Review 1.  Promoting brain remodeling to aid in stroke recovery.

Authors:  Zheng Gang Zhang; Michael Chopp
Journal:  Trends Mol Med       Date:  2015-08-13       Impact factor: 11.951

Review 2.  In vivo imaging of endogenous neural stem cells in the adult brain.

Authors:  Maria Adele Rueger; Michael Schroeter
Journal:  World J Stem Cells       Date:  2015-01-26       Impact factor: 5.326

Review 3.  Stem Cell-Mediated Regeneration of the Adult Brain.

Authors:  Sebastian Jessberger
Journal:  Transfus Med Hemother       Date:  2016-08-31       Impact factor: 3.747

4.  Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice.

Authors:  Somnath Ghosh; Chandrika Canugovi; Jeong Seon Yoon; David M Wilson; Deborah L Croteau; Mark P Mattson; Vilhelm A Bohr
Journal:  Neurobiol Aging       Date:  2015-04-17       Impact factor: 4.673

5.  Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation.

Authors:  Sebastian Preissl; Rongxin Fang; Hui Huang; Yuan Zhao; Ramya Raviram; David U Gorkin; Yanxiao Zhang; Brandon C Sos; Veena Afzal; Diane E Dickel; Samantha Kuan; Axel Visel; Len A Pennacchio; Kun Zhang; Bing Ren
Journal:  Nat Neurosci       Date:  2018-02-12       Impact factor: 24.884

6.  ChAT me up: how neurons control stem cells.

Authors:  Gregor-Alexander Pilz; Sebastian Jessberger
Journal:  Nat Neurosci       Date:  2014-07       Impact factor: 24.884

Review 7.  Function of neural stem cells in ischemic brain repair processes.

Authors:  Ruilan Zhang; Zhenggang Zhang; Michael Chopp
Journal:  J Cereb Blood Flow Metab       Date:  2016-10-14       Impact factor: 6.200

Review 8.  Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery.

Authors:  Peiying Li; R Anne Stetler; Rehana K Leak; Yejie Shi; Yan Li; Weifeng Yu; Michael V L Bennett; Jun Chen
Journal:  Neuropharmacology       Date:  2017-11-08       Impact factor: 5.250

Review 9.  Novel Insights into NeuN: from Neuronal Marker to Splicing Regulator.

Authors:  Wei Duan; Yu-Ping Zhang; Zhi Hou; Chen Huang; He Zhu; Chun-Qing Zhang; Qing Yin
Journal:  Mol Neurobiol       Date:  2015-02-14       Impact factor: 5.590

10.  In vivo evidence of hippocampal dentate gyrus expansion in multiple sclerosis.

Authors:  Maria A Rocca; Giulia Longoni; Elisabetta Pagani; Giacomo Boffa; Bruno Colombo; Mariaemma Rodegher; Gianvito Martino; Andrea Falini; Giancarlo Comi; Massimo Filippi
Journal:  Hum Brain Mapp       Date:  2015-08-19       Impact factor: 5.038
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