| Literature DB >> 23746839 |
Kirsty L Spalding1, Olaf Bergmann1, Kanar Alkass1,2, Samuel Bernard3, Mehran Salehpour4, Hagen B Huttner1,5, Emil Boström1, Isabelle Westerlund1, Celine Vial3, Bruce A Buchholz6, Göran Possnert4, Deborah C Mash7, Henrik Druid2, Jonas Frisén1.
Abstract
Adult-born hippocampal neurons are important for cognitive plasticity in rodents. There is evidence for hippocampal neurogenesis in adult humans, although whether its extent is sufficient to have functional significance has been questioned. We have assessed the generation of hippocampal cells in humans by measuring the concentration of nuclear-bomb-test-derived ¹⁴C in genomic DNA, and we present an integrated model of the cell turnover dynamics. We found that a large subpopulation of hippocampal neurons constituting one-third of the neurons is subject to exchange. In adult humans, 700 new neurons are added in each hippocampus per day, corresponding to an annual turnover of 1.75% of the neurons within the renewing fraction, with a modest decline during aging. We conclude that neurons are generated throughout adulthood and that the rates are comparable in middle-aged humans and mice, suggesting that adult hippocampal neurogenesis may contribute to human brain function.Entities:
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Year: 2013 PMID： 23746839 PMCID： PMC4394608 DOI： 10.1016/j.cell.2013.05.002
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582