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Literature DB >> 24747162

Macromolecular therapeutics.

Abstract

This review covers water-soluble polymer-drug conjugates and macromolecules that possess biological activity without attached low molecular weight drugs. The main design principles of traditional and backbone degradable polymer-drug conjugates as well as the development of a new paradigm in nanomedicines - (low molecular weight) drug-free macromolecular therapeutics are discussed. To address the biological features of cancer, macromolecular therapeutics directed to stem/progenitor cells and the tumor microenvironment are deliberated. Finally, the future perspectives of the field are briefly debated.

Entities: CellLine Chemical Disease Gene Species

Keywords: Cancer; Degradable polymeric carriers; Drug-free macromolecular therapeutics; Macromolecular therapeutics; N-(2-hydroxypropyl)methacrylamide; Water-soluble polymers

Mesh：

Substances：

Year: 2014 PMID： 24747162 PMCID： PMC4142088 DOI： 10.1016/j.jconrel.2014.04.013

Source DB: PubMed Journal: J Control Release ISSN： 0168-3659 Impact factor: 9.776

195 in total

1. Synthesis and in vitro characterization of semitelechelic poly[N-(2-hydroxypropyl)methacrylamide]-trastuzumab conjugates targeted to breast cancer.

Authors: Jun H Lee; Gauri Sabnis; Anjan Nan
Journal: Macromol Biosci Date: 2011-08-25 Impact factor: 4.979

2. New types of synthetic infusion solutions. I. Investigation of the effect of solutions of some hydrophilic polymers on blood.

Authors: J Kopecek; L Sprincl; D Lïm
Journal: J Biomed Mater Res Date: 1973-03

3. Refolding hydrogels self-assembled from N-(2-hydroxypropyl)methacrylamide graft copolymers by antiparallel coiled-coil formation.

Authors: Jiyuan Yang; Chunyu Xu; Chun Wang; Jindrich Kopecek
Journal: Biomacromolecules Date: 2006-04 Impact factor: 6.988

4. HPMA copolymer-doxorubicin conjugates: The effects of molecular weight and architecture on biodistribution and in vivo activity.

Authors: Tomáš Etrych; Vladimír Subr; Jiří Strohalm; Milada Sírová; Blanka Ríhová; Karel Ulbrich
Journal: J Control Release Date: 2012-06-30 Impact factor: 9.776

5. Effect of chain length on the formation and stability of synthetic alpha-helical coiled coils.

Authors: J Y Su; R S Hodges; C M Kay
Journal: Biochemistry Date: 1994-12-27 Impact factor: 3.162

6. Water-soluble porphyrin-polyethylene glycol conjugates with enhanced cellular uptake for photodynamic therapy.

Authors: Won Jin Kim; Min Soo Kang; Hwan Kyu Kim; Youngtak Kim; Taihyun Chang; Tymish Ohulchanskyy; Paras N Prasad; Kwang-Sup Lee
Journal: J Nanosci Nanotechnol Date: 2009-12

7. Dynamic light scattering study of self-assembly of HPMA hybrid graft copolymers.

Authors: Jiyuan Yang; Kuangshi Wu; Cestmír Konák; Jindrich Kopecek
Journal: Biomacromolecules Date: 2008-01-22 Impact factor: 6.988

8. ABC transporters in cancer: more than just drug efflux pumps.

Authors: Jamie I Fletcher; Michelle Haber; Michelle J Henderson; Murray D Norris
Journal: Nat Rev Cancer Date: 2010-01-15 Impact factor: 60.716

9. Synthesis and evaluation of multivalent branched HPMA copolymer-Fab' conjugates targeted to the B-cell antigen CD20.

Authors: Russell N Johnson; Pavla Kopecková; Jindrich Kopecek
Journal: Bioconjug Chem Date: 2009-01 Impact factor: 4.774

10. Drug-free macromolecular therapeutics: induction of apoptosis by coiled-coil-mediated cross-linking of antigens on the cell surface.

Authors: Kuangshi Wu; Jihua Liu; Russell N Johnson; Jiyuan Yang; Jindrich Kopecek
Journal: Angew Chem Int Ed Engl Date: 2010-02-15 Impact factor: 15.336

13 in total

1. A tumor-targeted polymer theranostics platform for positron emission tomography and fluorescence imaging.

Authors: Eva Koziolová; Shreya Goel; Petr Chytil; Olga Janoušková; Todd E Barnhart; Weibo Cai; Tomáš Etrych
Journal: Nanoscale Date: 2017-08-03 Impact factor: 7.790

Review 2. Drug Carriers: Not an Innocent Delivery Man.

Authors: Yoon Yeo; Bieong-Kil Kim
Journal: AAPS J Date: 2015-05-28 Impact factor: 4.009

Review 3. Design of smart HPMA copolymer-based nanomedicines.

Authors: Jiyuan Yang; Jindřich Kopeček
Journal: J Control Release Date: 2015-10-03 Impact factor: 9.776

4. Enhancing Accumulation and Penetration of HPMA Copolymer-Doxorubicin Conjugates in 2D and 3D Prostate Cancer Cells via iRGD Conjugation with an MMP-2 Cleavable Spacer.

Authors: Zheng-Hong Peng; Jindřich Kopeček
Journal: J Am Chem Soc Date: 2015-05-19 Impact factor: 15.419