Patricia Fauque1, Philippe Lehert2, Marjorie Lamotte3, Karima Bettahar-Lebugle4, Alphée Bailly5, Catherine Diligent6, Michel Clédat7, Paul Pierrot8, Marie-Lorraine Guénédal9, Paul Sagot3. 1. Laboratoire de Biologie de la Reproduction, Hôpital de Dijon, Université de Bourgogne, Dijon, France. Electronic address: patricia.fauque@chu-dijon.fr. 2. Faculty of Medicine, University of Melbourne, Victoria, Australia, and Faculty of Economics, Louvain University, Louvain-la-Neuve, Belgium. 3. Médecine Fœtale et Stérilité Conjugale, Service de Gynécologie-Obstétrique, Hôpital de Dijon, Université de Bourgogne, Dijon, France. 4. Centre d'Assistance Médicale à la Procréation, CMCO-SIHCUS, Schiltigheim, France. 5. Laboratoire de Biologie de la Reproduction, Université de Franche-Comté, Hôpital de Besançon, Besançon, France. 6. Unité de Biologie de la Reproduction, Université de Lorraine, Maternité Régionale Universitaire de Nancy, Nancy, France. 7. Polyclinique Majorelle, Nancy, France. 8. Centre FIV de Haute Alsace, Mulhouse, France. 9. Laboratoire du Vignoble, Kaysersberg, France.
Abstract
OBJECTIVE: To determine the impact of the time interval from the end of sperm preparation (TSP) to intrauterine insemination (IUI) on the outcome. DESIGN: Prospective multicentre cohort study. SETTING: Seven French centers (assisted reproduction group in northeastern France, four academic centers, and three clinics). PATIENT(S): Eight hundred sixty-two IUI cycles (709 patients) managed by gonadotropins were studied. INTERVENTION(S): Cycles were stimulated by either FSH or hMG, and hCG was administrated when the leading follicle diameter measured >15 mm. IUIs were performed ∼ 36 hours after ovulation triggering. MAIN OUTCOME MEASURE(S): Generalized linear mixed models for binary outcomes were used to model clinical pregnancy (CP) to assess the effect of TSP adjusted for other predictors (such as maternal age, semen quality, and indication of IUI treatment). RESULT(S): The TSP effect was significant, featuring an inverse U-shaped curve admitting an optimum interval of ∼ 40-80 minutes improving CP compared with other values. Other significant predictors were total motile spermatozoa inseminated, maternal age, and unexplained infertility. CONCLUSION(S): The observance of TSP in the range of 40-80 minutes has a potential positive effect on pregnancy rate, while not requiring the investment of supplemental resources. This finding awaits confirmation in randomized trials.
OBJECTIVE: To determine the impact of the time interval from the end of sperm preparation (TSP) to intrauterine insemination (IUI) on the outcome. DESIGN: Prospective multicentre cohort study. SETTING: Seven French centers (assisted reproduction group in northeastern France, four academic centers, and three clinics). PATIENT(S): Eight hundred sixty-two IUI cycles (709 patients) managed by gonadotropins were studied. INTERVENTION(S): Cycles were stimulated by either FSH or hMG, and hCG was administrated when the leading follicle diameter measured >15 mm. IUIs were performed ∼ 36 hours after ovulation triggering. MAIN OUTCOME MEASURE(S): Generalized linear mixed models for binary outcomes were used to model clinical pregnancy (CP) to assess the effect of TSP adjusted for other predictors (such as maternal age, semen quality, and indication of IUI treatment). RESULT(S): The TSP effect was significant, featuring an inverse U-shaped curve admitting an optimum interval of ∼ 40-80 minutes improving CP compared with other values. Other significant predictors were total motile spermatozoa inseminated, maternal age, and unexplained infertility. CONCLUSION(S): The observance of TSP in the range of 40-80 minutes has a potential positive effect on pregnancy rate, while not requiring the investment of supplemental resources. This finding awaits confirmation in randomized trials.
Authors: U Punjabi; H Van Mulders; L Van de Velde; I Goovaerts; K Peeters; W Cassauwers; T Lyubetska; K Clasen; P Janssens; O Zemtsova; E Roelant; D De Neubourg Journal: J Assist Reprod Genet Date: 2021-01-05 Impact factor: 3.412
Authors: Fernanda Sicchieri; Aline Bomfim Silva; Ana Carolina Japur de Sá Rosa E Silva; Paula Andrea de Albuquerque Sales Navarro; Rui Alberto Ferriani; Rosana Maria Dos Reis Journal: JBRA Assist Reprod Date: 2018-03-01