Fermín García-Muñoz Rodrigo1, Gloria M Galán Henríquez2, Cristina Gómez Ospina2. 1. Servicio de Neonatología, Hospital Universitario Materno Infantil de Las Palmas, Las Palmas de Gran Canaria, Spain. Electronic address: fgarciamu@gmail.com. 2. Servicio de Neonatología, Hospital Universitario Materno Infantil de Las Palmas, Las Palmas de Gran Canaria, Spain.
Abstract
BACKGROUND: Controversy exists about the relationship between maternal inflammation and the development of different morbidities and mortality in the newborn. We aimed to establish the incidence of clinical chorioamnionitis in our Neonatal Intensive Care Unit and its relation to morbidity and mortality among very-low-birth-weight infants. METHODS: This was an observational study of a cohort of very-low-birth-weight neonates admitted to our Neonatal Intensive Care Unit, between January 2008 and December 2012. Demographic characteristics and outcomes were analyzed and a comparison between exposed and non-exposed infants was carried out. RESULTS: During the study period, 451 very-low-birth-weight infants were admitted to our Neonatal Intensive Care Unit, and 31 (6.87%) were exposed to maternal clinical chorioamnionitis. The incidence was higher at lower gestational ages: 13.2% (23-26 weeks), 8.1% (27-30 weeks), and 2.6% (31-34 weeks) (p = 0.022). After correcting by gestational age and birth weight, early-onset neonatal sepsis (adjusted relative risk = 6.13; 95% confidence interval = 1.67-22.58; p = 0.006) and periventricular leukomalacia (adjusted relative risk = 24.62; 95% confidence interval = 1.87-324.28; p = 0.015) were significantly associated with maternal clinical chorioamnionitis. There were no differences in mortality or in survival without major morbidity. CONCLUSION: Clinical chorioamnionitis confers an increased risk of early-onset neonatal sepsis and periventricular leukomalacia to exposed very-low-birth-weight infants.
BACKGROUND: Controversy exists about the relationship between maternal inflammation and the development of different morbidities and mortality in the newborn. We aimed to establish the incidence of clinical chorioamnionitis in our Neonatal Intensive Care Unit and its relation to morbidity and mortality among very-low-birth-weight infants. METHODS: This was an observational study of a cohort of very-low-birth-weight neonates admitted to our Neonatal Intensive Care Unit, between January 2008 and December 2012. Demographic characteristics and outcomes were analyzed and a comparison between exposed and non-exposed infants was carried out. RESULTS: During the study period, 451 very-low-birth-weight infants were admitted to our Neonatal Intensive Care Unit, and 31 (6.87%) were exposed to maternal clinical chorioamnionitis. The incidence was higher at lower gestational ages: 13.2% (23-26 weeks), 8.1% (27-30 weeks), and 2.6% (31-34 weeks) (p = 0.022). After correcting by gestational age and birth weight, early-onset neonatal sepsis (adjusted relative risk = 6.13; 95% confidence interval = 1.67-22.58; p = 0.006) and periventricular leukomalacia (adjusted relative risk = 24.62; 95% confidence interval = 1.87-324.28; p = 0.015) were significantly associated with maternal clinical chorioamnionitis. There were no differences in mortality or in survival without major morbidity. CONCLUSION: Clinical chorioamnionitis confers an increased risk of early-onset neonatal sepsis and periventricular leukomalacia to exposed very-low-birth-weight infants.
Authors: T Myntti; L Rahkonen; A Pätäri-Sampo; M Tikkanen; T Sorsa; J Juhila; O Helve; S Andersson; J Paavonen; V Stefanovic Journal: J Perinatol Date: 2016-09-01 Impact factor: 2.521
Authors: Roberto Romero; Piya Chaemsaithong; Nikolina Docheva; Steven J Korzeniewski; Adi L Tarca; Gaurav Bhatti; Zhonghui Xu; Juan P Kusanovic; Zhong Dong; Noppadol Chaiyasit; Ahmed I Ahmed; Bo Hyun Yoon; Sonia S Hassan; Tinnakorn Chaiworapongsa; Lami Yeo Journal: J Perinat Med Date: 2016-01 Impact factor: 1.901
Authors: Roberto Romero; Piya Chaemsaithong; Nikolina Docheva; Steven J Korzeniewski; Adi L Tarca; Gaurav Bhatti; Zhonghui Xu; Juan P Kusanovic; Noppadol Chaiyasit; Zhong Dong; Bo Hyun Yoon; Sonia S Hassan; Tinnakorn Chaiworapongsa; Lami Yeo; Yeon Mee Kim Journal: J Perinat Med Date: 2016-01 Impact factor: 1.901