Literature DB >> 24745612

Biological effects of (125)i seeds radiation on A549 lung cancer cells: G2/M arrest and enhanced cell death.

Ang Qu1, Hao Wang, Jinna Li, Junjie Wang, Jingjia Liu, Yuzhu Hou, Li Huang, Yong Zhao.   

Abstract

External beam radiation (EBRT) and (125)I seeds continuous low dose rate radiation (CLDR) were used to treat patients with lung cancer. We herein investigated the biological effects of EBRT and CLDR on lung cancer cells. A549 human lung cancer cell line was thus exposed to different doses of EBRT and CLDR. CLDR was more efficient to inhibit cell growth than EBRT. CLDR induced increased DNA damage as evidenced by long-lasting p-H2AX activity. The enhanced inhibitory effects of CLDR on lung cancer cell growth may be, at least in part, due to the increased Bax/Bcl2 ratio and cyclin B1-mediated G2/M arrest.

Entities:  

Keywords:  125I continuous low dose rate radiation; DNA double-strand breaks; Lung cancer; Single external beam radiation

Mesh：

Substances：

Year:  2014        PMID： 24745612     DOI： 10.3109/07357907.2014.905585

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  21 in total

1.  Anacardic acid sensitizes prostate cancer cells to radiation therapy by regulating H2AX expression.

Authors:  Kun Yao; Xianzhen Jiang; Leye He; Yuxin Tang; Guangming Yin; Qing Zeng; Zhiqiang Jiang; Jing Tan
Journal:  Int J Clin Exp Pathol       Date:  2015-12-01

2.  Iodine-125 seed implantation combined with arterial chemoembolization therapy for pain palliation in metastatic bone cancer: a retrospective study.

Authors:  Zeran Yang; Guang Chen; Ye Cui; Tianhao Su; Jianan Yu; Guowen Xiao; Yanjing Han; Long Jin
Journal:  Cancer Biol Ther       Date:  2018-10-08       Impact factor: 4.742

3.  Glutamine synthetase facilitates cancer cells to recover from irradiation-induced G2/M arrest.

Authors:  Yanni Peng; Shujun Fu; Wenfeng Hu; Yanfang Qiu; Lu Zhang; Rong Tan; Lun-Quan Sun
Journal:  Cancer Biol Ther       Date:  2019-09-17       Impact factor: 4.742

Review 4.  Influential Factors and Synergies for Radiation-Gene Therapy on Cancer.

Authors:  Mei Lin; Junxing Huang; Yujuan Shi; Yanhong Xiao; Ting Guo
Journal:  Anal Cell Pathol (Amst)       Date:  2015-12-09       Impact factor: 2.916

5.  125I Seeds Radiation Induces Paraptosis-Like Cell Death via PI3K/AKT Signaling Pathway in HCT116 Cells.

Authors:  Lelin Hu; Hao Wang; Yong Zhao; Junjie Wang
Journal:  Biomed Res Int       Date:  2016-12-19       Impact factor: 3.411

6.  Dosimetry Verification of 125I Seeds Implantation With Three-Dimensional Printing Noncoplanar Templates and CT Guidance for Paravertebral/Retroperitoneal Malignant Tumors.

Authors:  Zhe Ji; Yuliang Jiang; Liang Su; Fuxin Guo; Ran Peng; Haitao Sun; Jinghong Fan; Junjie Wang
Journal:  Technol Cancer Res Treat       Date:  2017-08-07

7.  Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle.

Authors:  Aneta Węgierek-Ciuk; Michał Arabski; Karol Ciepluch; Kamil Brzóska; Halina Lisowska; Malwina Czerwińska; Tomasz Stępkowski; Krzysztof Lis; Anna Lankoff
Journal:  Int J Mol Sci       Date:  2021-05-28       Impact factor: 5.923

8.  The Clinical Value of Computed Tomography (CT)-Guided 125I Brachytherapy for Locally Advanced Non-Small Cell Lung Cancer After Progression of Concurrent Radiochemotherapy.

Authors:  Zhanwang Xiang; Zhihui Zhong; Luwen Mu; Guohong Li; Churen Zhou; Haofan Wang; Mingsheng Huang
Journal:  Cancer Manag Res       Date:  2021-07-05       Impact factor: 3.989

9.  A comparison of the biological effects of 125I seeds continuous low-dose-rate radiation and 60Co high-dose-rate gamma radiation on non-small cell lung cancer cells.

Authors:  Zhongmin Wang; Zhenzhen Zhao; Jian Lu; Zhijin Chen; Aiwu Mao; Gaojun Teng; Fenju Liu
Journal:  PLoS One       Date:  2015-08-12       Impact factor: 3.240

10.  125I Brachytherapy in Locally Advanced Nonsmall Cell Lung Cancer After Progression of Concurrent Radiochemotherapy.

Authors:  Zhanwang Xiang; Guohong Li; Zhenyin Liu; Jinhua Huang; Zhihui Zhong; Lin Sun; Chuanxing Li; Funjun Zhang
Journal:  Medicine (Baltimore)       Date:  2015-12       Impact factor: 1.817
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