Literature DB >> 24741097

Vaginal myeloid dendritic cells transmit founder HIV-1.

Ruizhong Shen1, John C Kappes2, Lesley E Smythies3, Holly E Richter4, Lea Novak5, Phillip D Smith6.   

Abstract

We report that primary human vaginal dendritic cells (DCs) display a myeloid phenotype and express CD4, CCR5, and CXCR4. Vaginal CD13(+) CD11c(+) DCs rapidly and efficiently bound transmitted/founder (T/F) CCR5-tropic (R5) viruses, transported them through explanted vaginal mucosa, and transmitted them in trans to vaginal and blood lymphocytes. Vaginal myeloid DCs may play a key role in capturing and disseminating T/F R5 HIV-1 in vivo and are candidate "gatekeeper" cells in HIV-1 transmission.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24741097      PMCID： PMC4054437          DOI： 10.1128/JVI.00766-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

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Review 2.  Interactions between HIV-1 and mucosal cells in the female reproductive tract.

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Review 7.  Bottlenecks in HIV-1 transmission: insights from the study of founder viruses.

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10.  Complement-Opsonized HIV Modulates Pathways Involved in Infection of Cervical Mucosal Tissues: A Transcriptomic and Proteomic Study.

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