Bartholomew N Ondigo1, James S Hodges2, Kathleen F Ireland3, Ng'wena G Magak4, David E Lanar5, Sheetij Dutta5, David L Narum6, Gregory S Park7, Ayub V Ofulla7, Chandy C John8. 1. Department of Biomedical Science and Technology, Maseno University Center for Global Health Research, Kenya Medical Research Institute, Kisumu. 2. Division of Biostatistics, School of Public Health, University of Minnesota. 3. Department of Pediatrics, University of Minnesota Medical School. 4. Department of Medical Physiology, Maseno University, Kenya. 5. Center for Global Health Research, Kenya Medical Research Institute, Kisumu. 6. Malaria Vaccine Branch, Walter Reed Army Institute for Research, Silver Spring. 7. Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, National Institute of Health, Rockville, Maryland. 8. Department of Pediatrics, University of Minnesota Medical School Center for Global Health Research, Kenya Medical Research Institute, Kisumu.
Abstract
BACKGROUND: Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs. METHODS: The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission. RESULTS: Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (<40% positive by age 20 years, 3 antigens). Antibody seroreversion rates in the 14 months between samples decreased with age rapidly (7 antigens), slowly (3 antigens), or remained high at all ages (schizont extract). Estimated antibody half-lives in individuals >10 years of age were long (40 to >80 years) for 5 antigens, moderate (5-20 years) for 3 antigens, and short (<1 year) for 3 antigens. CONCLUSIONS: Antibodies to P. falciparum antigens in malaria-endemic areas vary by age, antigen, and time since last exposure to P. falciparum. Multiplex P. falciparum antibody testing could provide estimates of long-term and recent malaria transmission and potentially of a population's susceptibility to future clinical malaria.
BACKGROUND: Tools that estimate recent and long-term malaria transmission in a population would be highly useful for malaria elimination programs. METHODS: The prevalence of antibodies to 11 Plasmodium falciparum antigens was assessed by cytometric bead assay or enzyme-linked immunosorbent assay in 1000 people in a highland area of Kenya over 14 months, during a period of interrupted malaria transmission. RESULTS: Antibodies differed by antigen in acquisition with age: rapid (>80% antibody positive by age 20 years, 5 antigens), moderate (>40% positive by age 20 years, 3 antigens), or slow (<40% positive by age 20 years, 3 antigens). Antibody seroreversion rates in the 14 months between samples decreased with age rapidly (7 antigens), slowly (3 antigens), or remained high at all ages (schizont extract). Estimated antibody half-lives in individuals >10 years of age were long (40 to >80 years) for 5 antigens, moderate (5-20 years) for 3 antigens, and short (<1 year) for 3 antigens. CONCLUSIONS: Antibodies to P. falciparum antigens in malaria-endemic areas vary by age, antigen, and time since last exposure to P. falciparum. Multiplex P. falciparum antibody testing could provide estimates of long-term and recent malaria transmission and potentially of a population's susceptibility to future clinical malaria.
Authors: Teun Bousema; Randa M Youssef; Jackie Cook; Jonathan Cox; Victor A Alegana; Jamal Amran; Abdisalan M Noor; Robert W Snow; Chris Drakeley Journal: Emerg Infect Dis Date: 2010-03 Impact factor: 6.883
Authors: Chandy C John; Aaron J Tande; Ann M Moormann; Peter O Sumba; David E Lanar; Xinan M Min; James W Kazura Journal: J Infect Dis Date: 2008-02-15 Impact factor: 5.226
Authors: David M Menge; Kacey C Ernst; John M Vulule; Peter A Zimmerman; Hongfei Guo; Chandy C John Journal: Am J Trop Med Hyg Date: 2008-08 Impact factor: 2.345
Authors: Onome J Akpogheneta; Nancy O Duah; Kevin K A Tetteh; Samuel Dunyo; David E Lanar; Margaret Pinder; David J Conway Journal: Infect Immun Date: 2008-01-22 Impact factor: 3.441
Authors: Daniel Dodoo; Michael R Hollingdale; Dorothy Anum; Kwadwo A Koram; Ben Gyan; Bartholomew D Akanmori; Josephine Ocran; Susan Adu-Amankwah; Harini Geneshan; Esteban Abot; Jennylyn Legano; Glenna Banania; Renato Sayo; Donald Brambilla; Sanjai Kumar; Denise L Doolan; William O Rogers; Judith Epstein; Thomas L Richie; Martha Sedegah Journal: Malar J Date: 2011-06-20 Impact factor: 2.979
Authors: Scott D Nash; D Rebecca Prevots; Edward Kabyemela; Yogender P Khasa; Kun-Lin Lee; Michal Fried; Patrick E Duffy Journal: Am J Trop Med Hyg Date: 2017-05 Impact factor: 2.345
Authors: Natalie M Bowman; Jonathan J Juliano; Cynthia J Snider; Oksana Kharabora; Steven R Meshnick; John Vulule; Chandy C John; Ann M Moormann Journal: Am J Trop Med Hyg Date: 2016-08-01 Impact factor: 2.345
Authors: Eric Rogier; Delynn M Moss; Anna N Chard; Victoria Trinies; Seydou Doumbia; Matthew C Freeman; Patrick J Lammie Journal: Am J Trop Med Hyg Date: 2016-11-28 Impact factor: 2.345
Authors: Vashti Irani; Paul A Ramsland; Andrew J Guy; Peter M Siba; Ivo Mueller; Jack S Richards; James G Beeson Journal: Clin Infect Dis Date: 2015-07-01 Impact factor: 9.079
Authors: Fiona J McCallum; Kristina E M Persson; Freya J I Fowkes; Linda Reiling; Cleopatra K Mugyenyi; Jack S Richards; Julie A Simpson; Thomas N Williams; Paul R Gilson; Anthony N Hodder; Paul R Sanders; Robin F Anders; David L Narum; Chetan Chitnis; Brendan S Crabb; Kevin Marsh; James G Beeson Journal: J Leukoc Biol Date: 2016-11-11 Impact factor: 4.962
Authors: Eric Rogier; Doug Nace; Pedro R Dimbu; Brian Wakeman; James G Beeson; Chris Drakeley; Kevin Tetteh; Mateusz Plucinski Journal: Front Med (Lausanne) Date: 2022-07-19
Authors: Danica A Helb; Kevin K A Tetteh; Philip L Felgner; Jeff Skinner; Alan Hubbard; Emmanuel Arinaitwe; Harriet Mayanja-Kizza; Isaac Ssewanyana; Moses R Kamya; James G Beeson; Jordan Tappero; David L Smith; Peter D Crompton; Philip J Rosenthal; Grant Dorsey; Christopher J Drakeley; Bryan Greenhouse Journal: Proc Natl Acad Sci U S A Date: 2015-07-27 Impact factor: 11.205
Authors: Anne E P Frosch; Bartholomew N Ondigo; George A Ayodo; John M Vulule; Chandy C John; Sarah E Cusick Journal: Am J Clin Nutr Date: 2014-07-30 Impact factor: 7.045
Authors: Bartholomew N Ondigo; Karen E S Hamre; Anne E P Frosch; George Ayodo; Michael T White; Chandy C John Journal: Am J Trop Med Hyg Date: 2020-10-27 Impact factor: 3.707