Literature DB >> 2440718

Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage-dependent Na+ channel.

A Lombet, J N Bidard, M Lazdunski.   

Abstract

Binding studies indicate that ciguatoxin and brevetoxin allosterically enhance in a very similar way the binding of [3H]batrachotoxinin A 20-alpha-benzoate to the neuronal Na+ channel protein. Moreover ciguatoxin competitively inhibits the binding of [3H]brevetoxin-3 to rat brain membranes. The affinity of ciguatoxin for the Na+ channel is at least 20-50-times higher than that of brevetoxin. These results indicate that ciguatoxin and brevetoxins act at the same binding site on the sodium channel.

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Year:  1987        PMID： 2440718     DOI： 10.1016/0014-5793(87)80252-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  48 in total

Review 1.  Sodium channel toxins and neurotransmitter release.

Authors:  André Ricardo Massensini; Marco Aurélio Romano-Silva; Marcus Vinícius Gomez
Journal:  Neurochem Res       Date:  2003-10       Impact factor: 3.996

2.  Brevetoxins, like ciguatoxins, are potent ichthyotoxic neurotoxins that accumulate in fish.

Authors:  Jerome P Naar; Leanne J Flewelling; Allison Lenzi; Jay P Abbott; April Granholm; Henry M Jacocks; Damon Gannon; Michael Henry; Richard Pierce; Daniel G Baden; Jennifer Wolny; Jan H Landsberg
Journal:  Toxicon       Date:  2007-06-26       Impact factor: 3.033

Review 3.  Sodium channels and pain: from toxins to therapies.

Authors:  Fernanda C Cardoso; Richard J Lewis
Journal:  Br J Pharmacol       Date:  2017-09-02       Impact factor: 8.739

Review 4.  Animal toxins influence voltage-gated sodium channel function.

Authors:  John Gilchrist; Baldomero M Olivera; Frank Bosmans
Journal:  Handb Exp Pharmacol       Date:  2014

5.  Inhibition by propofol of [3H]-batrachotoxinin-A 20-alpha-benzoate binding to voltage-dependent sodium channels in rat cortical synaptosomes.

Authors:  L Ratnakumari; H C Hemmings
Journal:  Br J Pharmacol       Date:  1996-12       Impact factor: 8.739

6.  Sub-nanomolar concentrations of ciguatoxin-1 excite preganglionic terminals in guinea pig sympathetic ganglia.

Authors:  P A Hamblin; E M McLachlan; R J Lewis
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1995-08       Impact factor: 3.000

7.  Neuroprotective effects of rosmarinic acid on ciguatoxin in primary human neurons.

Authors:  N Braidy; A Matin; F Rossi; M Chinain; D Laurent; G J Guillemin
Journal:  Neurotox Res       Date:  2013-10-05       Impact factor: 3.911

8.  First- and second-generation total synthesis of ciguatoxin CTX3C.

Authors:  Masayuki Inoue; Keisuke Miyazaki; Hisatoshi Uehara; Megumi Maruyama; Masahiro Hirama
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-15       Impact factor: 11.205

9.  A quantitative and comparative study of the effects of a synthetic ciguatoxin CTX3C on the kinetic properties of voltage-dependent sodium channels.

Authors:  Kaoru Yamaoka; Masayuki Inoue; Hidemichi Miyahara; Keisuke Miyazaki; Masahiro Hirama
Journal:  Br J Pharmacol       Date:  2004-06-14       Impact factor: 8.739

10.  Characterization of [3H]brevetoxin binding to voltage-dependent sodium channels in adrenal medullary cells.

Authors:  T Yuhi; A Wada; R Yamamoto; M Urabe; H Niina; F Izumi; T Yanagita
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-08       Impact factor: 3.000
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