Literature DB >> 2473616

Cimetidine and ketotifen inhibit stimulated aggregation and histamine liberation from rabbit blood platelets.

V Jancinová1, R Nosál.   

Abstract

The effect of cimetidine and ketotifen was studied on thrombin-stimulated rabbit platelet aggregation as well as on histamine and serotonin liberation. Both drugs inhibited the stimulation of platelets in a dose-dependent way. The effect of ketotifen on stimulated aggregation was about twice that of cimetidine. Stimulated histamine and serotonin liberation was more inhibited by ketotifen than by cimetidine. Both drugs inhibited the liberation of serotonin to a greater extent than that of histamine.

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Year:  1989        PMID： 2473616     DOI： 10.1007/bf02222220

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

1.  Aggregation of blood platelets by adenosine diphosphate and its reversal.

Authors:  G V BORN
Journal:  Nature       Date:  1962-06-09       Impact factor: 49.962

2.  Factors affecting the uptake of 5-hydroxytryptamine by human platelets in an inorganic medium.

Authors:  H WEISSBACH; B G REDFIELD
Journal:  J Biol Chem       Date:  1960-11       Impact factor: 5.157

3.  A method for the fluorometric assay of histamine in tissues.

Authors:  P A SHORE; A BURKHALTER; V H COHN
Journal:  J Pharmacol Exp Ther       Date:  1959-11       Impact factor: 4.030

4.  Intracellular calcium release induced by histamine releasers and its inhibition by some antiallergic drugs.

Authors:  K Tasaka; M Mio; M Okamoto
Journal:  Ann Allergy       Date:  1986-06

Review 5.  PAF-acether today--relevance for acute experimental anaphylaxis.

Authors:  B B Vargaftig; P G Braquet
Journal:  Br Med Bull       Date:  1987-04       Impact factor: 4.291

6.  Potassium-induced histamine release from mast cells and its inhibition by ketotifen.

Authors:  A Németh; P Magyar; R Herceg; Z Huszti
Journal:  Agents Actions       Date:  1987-04

7.  Cimetidine and somatostatin in gastroduodenal haemorrhage.

Authors:  D P Mikhailidis; A M Mikhailidis; P Dandona
Journal:  Lancet       Date:  1981-01-31       Impact factor: 79.321

8.  In vitro effect of cimetidine on platelet aggregation.

Authors:  D P Mikhailidis; M A Barradas; J Y Jeremy; P Dandona
Journal:  Thromb Res       Date:  1985-05-01       Impact factor: 3.944

9.  In vitro effect of cimetidine on ADP induced platelet aggregation and thromboxane A2 synthesis in man.

Authors:  B Gachályi; K Tihanyi; A Vas; A Káldor
Journal:  Thromb Res       Date:  1984-07-01       Impact factor: 3.944
  9 in total
  1 in total

1.  Antihistaminic drug bromadryl and stimulated platelet aggregation.

Authors:  R Nosál; V Jancinová; M Petríková
Journal:  Agents Actions       Date:  1994-06
  1 in total

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