Literature DB >> 2440257

Potassium-induced histamine release from mast cells and its inhibition by ketotifen.

A Németh, P Magyar, R Herceg, Z Huszti.   

Abstract

Potassium chloride induced a dose-dependent release of histamine from rat peritoneal mast cells at concentrations from 5 to 150 mM in the absence of extracellular Ca2+. Potassium concentrations greater than 150 mM produced less histamine release. The release was energy-dependent and was complete within one minute. The histamine liberating effect of KCl could be inhibited by NaCl and by preincubation with ketotifen. The monovalent cations, Rb+ and Cs+ also evoked histamine release, whereas Na+ and Li+ were ineffective.

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Year:  1987        PMID： 2440257     DOI： 10.1007/bf02074654

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  9 in total

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3.  Crosslinking of the receptors for immunoglobulin E depolarizes the plasma membrane of rat basophilic leukemia cells.

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Journal:  Proc Natl Acad Sci U S A       Date:  1983-09       Impact factor: 11.205

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Authors:  A Németh; P Röhlich
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Authors:  P Magyar; M Dervaderics; A Tóth
Journal:  Schweiz Med Wochenschr       Date:  1984-06-23

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Journal:  J Physiol       Date:  1976-05       Impact factor: 5.182

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Authors:  M Ennis; A Truneh; J R White; F L Pearce
Journal:  Nature       Date:  1981-01-15       Impact factor: 49.962

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Authors:  R Sagi-Eisenberg; I Pecht
Journal:  J Membr Biol       Date:  1983       Impact factor: 1.843

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Authors:  F L Pearce; J R White
Journal:  Agents Actions       Date:  1984-04
  9 in total
  5 in total

Review 1.  Ketotifen. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in asthma and allergic disorders.

Authors:  S M Grant; K L Goa; A Fitton; E M Sorkin
Journal:  Drugs       Date:  1990-09       Impact factor: 9.546

2.  Ouabain-insensitive 86Rb+ transport in peritoneal mast cells: role in histamine release.

Authors:  A Németh; Z Huszti
Journal:  Inflamm Res       Date:  1995-04       Impact factor: 4.575

3.  Cimetidine and ketotifen inhibit stimulated aggregation and histamine liberation from rabbit blood platelets.

Authors:  V Jancinová; R Nosál
Journal:  Agents Actions       Date:  1989-04

4.  Inhibition of potassium-induced release of histamine from mast cells by tetraethylammonium and tetramethylammonium.

Authors:  A Németh; P Magyar; Z Huszti
Journal:  Agents Actions       Date:  1990-04

5.  Chondroitin sulphate inhibits connective tissue mast cells.

Authors:  T C Theoharides; P Patra; W Boucher; R Letourneau; D Kempuraj; G Chiang; S Jeudy; L Hesse; A Athanasiou
Journal:  Br J Pharmacol       Date:  2000-11       Impact factor: 8.739
  5 in total

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