Literature DB >> 2473614

Staphylococcus aureus and influenza A virus stimulate human bronchoalveolar cells to release histamine and leukotrienes.

P Clementsen1, H Bisgaard, M Pedersen, H Permin, E Struve-Christensen, N Milman, B Nüchel-Petersen, S Norn.   

Abstract

Mediator release was examined from superficially lying cells in the airway epithelium obtained by bronchoalveolar lavage (BAL) in 13 non-atopic individuals. The BAL-cells were incubated (20 min, 37 degrees C) with Staphylococcus (Staph.) aureus or with human influenza A virus Staph. aureus was found to release histamine from cells from 7 of the 13 individuals and influenza A virus in 3 of 5 persons. Furthermore, Staph, aureus stimulated the BAL-cells to release leukotriene B4 in 7 of 11 subjects, whereas no release was found by influenza A virus in 7 examined persons. When cells from 4 persons were stimulated with Staph. aureus no release of leukotriene C4 was found. The mediator release caused by bacteria and virus might be of importance for the exacerbation of bronchial asthma in upper respiratory tract infections, since histamine is assumed to increase the epithelial permeability with entrance of allergens and other insulting particles, and leukotriene B4 facilitates airway inflammation.

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Year:  1989        PMID： 2473614     DOI： 10.1007/bf02222212

Source DB:  PubMed          Journal:  Agents Actions        ISSN： 0065-4299


  10 in total

1.  A method for the fluorometric assay of histamine in tissues.

Authors:  P A SHORE; A BURKHALTER; V H COHN
Journal:  J Pharmacol Exp Ther       Date:  1959-11       Impact factor: 4.030

2.  Endotoxins release histamine by complement activation and potentiate bacteria-induced histamine release.

Authors:  S Norn; C Jensen; B T Dahl; P Stahl Skov; L Baek; H Permin; J O Jarløv; H Sørensen
Journal:  Agents Actions       Date:  1986-04

3.  Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells.

Authors:  M K Church; S Norn; G J Pao; S T Holgate
Journal:  Clin Allergy       Date:  1987-07

4.  Bronchial mucosal permeability and its relationship to airways hyperreactivity.

Authors:  J C Hogg
Journal:  J Allergy Clin Immunol       Date:  1981-06       Impact factor: 10.793

5.  Mechanism of leukotriene generation in polymorphonuclear leukocytes by staphylococcal alpha-toxin.

Authors:  N Suttorp; W Seeger; J Zucker-Reimann; L Roka; S Bhakdi
Journal:  Infect Immun       Date:  1987-01       Impact factor: 3.441

6.  Influenza A virus enhances allergic histamine release. Effect of neuraminidase.

Authors:  P Clementsen; C Hannoun; S Norn
Journal:  Allergy       Date:  1989-01       Impact factor: 13.146

7.  Generation of leukotrienes and lipoxygenase factors from human polymorphonuclear granulocytes during bacterial phagocytosis and interaction with bacterial exotoxins.

Authors:  K D Bremm; J Brom; W König; B Spur; A Crea; S Bhakdi; F Lutz; F J Fehrenbach
Journal:  Zentralbl Bakteriol Mikrobiol Hyg A       Date:  1983-07

8.  Influenza A virus potentiates basophil histamine release caused by endotoxin-induced complement activation. Examination of normal individuals and patients with intrinsic asthma.

Authors:  P Clementsen; C B Jensen; C Hannoun; M Søborg; S Norn
Journal:  Allergy       Date:  1988-02       Impact factor: 13.146

9.  Histamine release induced by bacteria. A new mechanism in asthma?

Authors:  S Norn; P S Skov; C Jensen; J O Jarløv; F Espersen
Journal:  Agents Actions       Date:  1987-02

10.  Staphylococcus aureus peptidoglycan induces histamine release from basophil human leukocytes in vitro.

Authors:  F Espersen; J O Jarløv; C Jensen; P S Skov; S Norn
Journal:  Infect Immun       Date:  1984-12       Impact factor: 3.441
  10 in total
  6 in total

1.  Haemophilus influenzae potentiates basophil histamine release possibly by its endotoxins.

Authors:  S Norn; P Clementsen; A Fomsgaard; M Kilian
Journal:  Agents Actions       Date:  1990-04

2.  Limited replication of influenza A virus in human mast cells.

Authors:  Candy W Marcet; Chris D St Laurent; Tae Chul Moon; Nav Singh; A Dean Befus
Journal:  Immunol Res       Date:  2013-05       Impact factor: 2.829

3.  Influenza A virus enhances IgE-mediated histamine release from human basophil leukocytes. Examination of the effect of viral neuraminidase and haemagglutinin.

Authors:  P Clementsen; A R Douglas; J J Skehel; C Hannoun; N Bach-Mortensen; S Norn
Journal:  Agents Actions       Date:  1989-04

4.  5-Lipoxygenase reaction products modulate alveolar macrophage phagocytosis of Klebsiella pneumoniae.

Authors:  P Mancuso; T J Standiford; T Marshall; M Peters-Golden
Journal:  Infect Immun       Date:  1998-11       Impact factor: 3.441

5.  Bacteria-induced IgE-mediated histamine release: examination of patients with chronic bronchitis (CB) during acute exacerbations.

Authors:  S Norn; L Jensen; L L Kjaergaard; H Permin; P S Skov; F Espersen
Journal:  Agents Actions       Date:  1994-06

Review 6.  Microorganisms and exacerbation of chronic obstructive pulmonary diseases: pathophysiological mechanisms.

Authors:  P Clementsen; K S Kristensen; S Norn
Journal:  Allergy       Date:  1992-06       Impact factor: 13.146
  6 in total

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