Hiroki Kato1, Masayuki Kanematsu2, Haruo Watanabe3, Keisuke Mizuta4, Mitsuhiro Aoki5. 1. Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan(1). Electronic address: hkato@gifu-u.ac.jp. 2. Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan(1); High-level Imaging Diagnosis Center, Gifu University Hospital, 1-1 Yanagido, Gifu 501-1194, Japan(2). Electronic address: masa_gif@yahoo.co.jp. 3. Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan(1). Electronic address: haruwow860@yahoo.co.jp. 4. Department of Otolaryngology, Gifu University School of Medicine, Gifu, Japan(1). Electronic address: kmizuta@gifu-u.ac.jp. 5. Department of Otolaryngology, Gifu University School of Medicine, Gifu, Japan(1). Electronic address: aoki@gifu-u.ac.jp.
Abstract
PURPOSE: The purpose of this study was to compare the diagnostic accuracies of CT and MR imaging for the detection of metastatic retropharyngeal lymph nodes (RLNs) in patients with nasopharyngeal and oropharyngeal squamous cell carcinoma (SCC). MATERIALS AND METHODS: The study included 38 patients (28 men and 10 women; mean age, 65 years; age range, 48-82 years) with nasopharyngeal (n=15) and oropharyngeal (n=23) SCC who underwent both contrast-enhanced CT and MR imaging before chemoradiotherapy. RLNs were classified as malignant or benign on the basis of the results of follow-up MR imaging. Two radiologists independently evaluated the images for diagnosing metastatic RLNs. RESULTS: Among a total of 68 RLNs (minimum diameter, ≥ 4 mm) that were detected on gadolinium-enhanced fat-suppressed T1-weighted images, 30 (44%) were malignant and 38 (56%) were benign. The sensitivities of CT versus MRI were 60% versus 97% for observer 1 (p<0.01) and 37% versus 90% for observer 2 (p<0.01). The specificities of CT versus MRI were 92% versus 97% for observer 1 (p=0.50) and 92% versus 100% for observer 2 (p=0.25). The areas under the receiver operating characteristic curve (AUC) for CT versus MRI were 0.788 versus 0.996 for observer 1 (p<0.01) and 0.693 versus 0.961 for observer 2 (p<0.01). CONCLUSION: MR imaging was superior to CT for the detection of metastatic RLNs.
PURPOSE: The purpose of this study was to compare the diagnostic accuracies of CT and MR imaging for the detection of metastatic retropharyngeal lymph nodes (RLNs) in patients with nasopharyngeal and oropharyngeal squamous cell carcinoma (SCC). MATERIALS AND METHODS: The study included 38 patients (28 men and 10 women; mean age, 65 years; age range, 48-82 years) with nasopharyngeal (n=15) and oropharyngeal (n=23) SCC who underwent both contrast-enhanced CT and MR imaging before chemoradiotherapy. RLNs were classified as malignant or benign on the basis of the results of follow-up MR imaging. Two radiologists independently evaluated the images for diagnosing metastatic RLNs. RESULTS: Among a total of 68 RLNs (minimum diameter, ≥ 4 mm) that were detected on gadolinium-enhanced fat-suppressed T1-weighted images, 30 (44%) were malignant and 38 (56%) were benign. The sensitivities of CT versus MRI were 60% versus 97% for observer 1 (p<0.01) and 37% versus 90% for observer 2 (p<0.01). The specificities of CT versus MRI were 92% versus 97% for observer 1 (p=0.50) and 92% versus 100% for observer 2 (p=0.25). The areas under the receiver operating characteristic curve (AUC) for CT versus MRI were 0.788 versus 0.996 for observer 1 (p<0.01) and 0.693 versus 0.961 for observer 2 (p<0.01). CONCLUSION: MR imaging was superior to CT for the detection of metastatic RLNs.
Authors: Kee H Wong; Rafal Panek; Shreerang A Bhide; Christopher M Nutting; Kevin J Harrington; Katie L Newbold Journal: Br J Radiol Date: 2017-03 Impact factor: 3.039
Authors: Zsuzsanna Iyizoba-Ebozue; Louise J Murray; Moses Arunsingh; Karen E Dyker; Sriram Vaidyanathan; Andrew F Scarsbrook; Robin J D Prestwich Journal: Cancers (Basel) Date: 2019-12-29 Impact factor: 6.639