Feng Lin1, Rachel Roiland, Ding-Geng Din Chen, Christina Qiu. 1. School of Nursing, University of Rochester, Rochester, NY, USA; Department of Psychiatry, School of Medicine and Dentistry, University of Rochester, Rochester, NY, USA.
Abstract
OBJECTIVES: This study examined whether metabolic syndrome (MetS) would moderate the association of cognition with frailty in middle and old age. METHODS: A cross-sectional design was used. Six hundred and ninety participants (age ≥ 50 years) from an on-going national survey were included in the study. Confirmatory factor analysis was applied to determine latent variables of executive function (EF), episodic memory (EM), and MetS based on relevant measurements. Frailty was defined using a modified form of Fried's criteria. RESULTS: Applying structural equation modeling, having MetS significantly increased the likelihood of being frail. Better performance on EM tasks, but not EF, was significantly associated with lower likelihood of MetS. Worse performance on EF, but not EM, significantly increased the likelihood of being frail. There was a significant interacting effect between MetS and EF, but not EM, on frailty. Further contrast analysis indicated that having MetS strengthened the negative association between EF and frailty. CONCLUSION: Metabolic syndrome moderates the relationship between EF and frailty. A prospecitve study is needed to validate such relationships before developing interventions targeting the prevention or treatment of EF and frailty in individuals with MetS.
OBJECTIVES: This study examined whether metabolic syndrome (MetS) would moderate the association of cognition with frailty in middle and old age. METHODS: A cross-sectional design was used. Six hundred and ninety participants (age ≥ 50 years) from an on-going national survey were included in the study. Confirmatory factor analysis was applied to determine latent variables of executive function (EF), episodic memory (EM), and MetS based on relevant measurements. Frailty was defined using a modified form of Fried's criteria. RESULTS: Applying structural equation modeling, having MetS significantly increased the likelihood of being frail. Better performance on EM tasks, but not EF, was significantly associated with lower likelihood of MetS. Worse performance on EF, but not EM, significantly increased the likelihood of being frail. There was a significant interacting effect between MetS and EF, but not EM, on frailty. Further contrast analysis indicated that having MetS strengthened the negative association between EF and frailty. CONCLUSION:Metabolic syndrome moderates the relationship between EF and frailty. A prospecitve study is needed to validate such relationships before developing interventions targeting the prevention or treatment of EF and frailty in individuals with MetS.
Authors: L P Fried; C M Tangen; J Walston; A B Newman; C Hirsch; J Gottdiener; T Seeman; R Tracy; W J Kop; G Burke; M A McBurnie Journal: J Gerontol A Biol Sci Med Sci Date: 2001-03 Impact factor: 6.053
Authors: Justin E Karr; Corson N Areshenkoff; Philippe Rast; Scott M Hofer; Grant L Iverson; Mauricio A Garcia-Barrera Journal: Psychol Bull Date: 2018-08-06 Impact factor: 17.737
Authors: João Apóstolo; Richard Cooke; Elzbieta Bobrowicz-Campos; Silvina Santana; Maura Marcucci; Antonio Cano; Miriam Vollenbroek-Hutten; Federico Germini; Barbara D'Avanzo; Holly Gwyther; Carol Holland Journal: JBI Database System Rev Implement Rep Date: 2018-01