Xiaoman Jiang1, Xinyi Xu2, Lingyu Ding1, Jinling Lu3, Hanfei Zhu1, Kang Zhao1, Shuqin Zhu1, Qin Xu4. 1. School of Nursing, Nanjing Medical University, Nanjing, 211166, China. 2. Faculty of Health, Queensland University of Technology, Brisbane, 4702, Australia. 3. Department of Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 211166, China. 4. School of Nursing, Nanjing Medical University, Nanjing, 211166, China. qinxu@njmu.edu.cn.
Abstract
BACKGROUND: Frailty represents a progressive deterioration in multi-system of the body and could increase vulnerability to stressors. Recently, several studies found that metabolic syndrome was significantly associated with frailty and emphasized its role in assessing and preventing frailty. However, these conclusions are controversial. We conducted this systematic review and meta-analysis to evaluate the association between metabolic syndrome and frailty. METHODS: Databases including Pubmed, Embase, Web of Science, CINAHL Complete, China National Knowledge Infrastructure (CNKI) and Wanfang Data Knowledge Service Platform were searched for studies on the association between metabolic syndrome and frailty, from inception to 17th June 2022. Two researchers independently screened the literature, extracted the data and evaluated the quality. Stata/SE 15.0 software was used to perform the statistical analysis. RESULTS: Eleven studies were included in this review and eight studies were included in the meta-analysis, involving one prospective cohort studies and ten cross-sectional studies with 12,640 participants. The pooled results indicated that metabolic syndrome was significantly associated with frailty (OR = 1.82, 95% CI = 1.46-2.27) with a low heterogeneity (I2 = 32.1%), and there were significant associations between MetS and weakness (OR = 1.35, 95% CI = 1.15-1.58, I2 = 0.0%), slow gait speed (OR = 1.80, 95% CI = 1.51-2.14, I2 = 93.4%), weight loss (OR = 1.77, 95% CI = 1.36-2.29, I2 = 0.0%) and decreased physical activity (OR = 1.87, 95% CI = 1.49-2.35, I2 = 39.7%). CONCLUSIONS: The findings of this systematic review and meta-analysis suggested that metabolic syndrome could be significantly associated with the presence of frailly. Future studies need to further consider the effects of measurement tools, age and specific disease status in this association. Furthermore, the casual relationship between them is to be determined.
BACKGROUND: Frailty represents a progressive deterioration in multi-system of the body and could increase vulnerability to stressors. Recently, several studies found that metabolic syndrome was significantly associated with frailty and emphasized its role in assessing and preventing frailty. However, these conclusions are controversial. We conducted this systematic review and meta-analysis to evaluate the association between metabolic syndrome and frailty. METHODS: Databases including Pubmed, Embase, Web of Science, CINAHL Complete, China National Knowledge Infrastructure (CNKI) and Wanfang Data Knowledge Service Platform were searched for studies on the association between metabolic syndrome and frailty, from inception to 17th June 2022. Two researchers independently screened the literature, extracted the data and evaluated the quality. Stata/SE 15.0 software was used to perform the statistical analysis. RESULTS: Eleven studies were included in this review and eight studies were included in the meta-analysis, involving one prospective cohort studies and ten cross-sectional studies with 12,640 participants. The pooled results indicated that metabolic syndrome was significantly associated with frailty (OR = 1.82, 95% CI = 1.46-2.27) with a low heterogeneity (I2 = 32.1%), and there were significant associations between MetS and weakness (OR = 1.35, 95% CI = 1.15-1.58, I2 = 0.0%), slow gait speed (OR = 1.80, 95% CI = 1.51-2.14, I2 = 93.4%), weight loss (OR = 1.77, 95% CI = 1.36-2.29, I2 = 0.0%) and decreased physical activity (OR = 1.87, 95% CI = 1.49-2.35, I2 = 39.7%). CONCLUSIONS: The findings of this systematic review and meta-analysis suggested that metabolic syndrome could be significantly associated with the presence of frailly. Future studies need to further consider the effects of measurement tools, age and specific disease status in this association. Furthermore, the casual relationship between them is to be determined.
Authors: Rónán O'Caoimh; Duygu Sezgin; Mark R O'Donovan; D William Molloy; Andrew Clegg; Kenneth Rockwood; Aaron Liew Journal: Age Ageing Date: 2021-01-08 Impact factor: 10.668
Authors: Raúl F Pérez-Tasigchana; Luz M León-Muñoz; Esther Lopez-Garcia; Juan L Gutierrez-Fisac; Martín Laclaustra; Fernando Rodríguez-Artalejo; Pilar Guallar-Castillón Journal: Age Ageing Date: 2017-09-01 Impact factor: 10.668
Authors: Robbert J J Gobbens; Katrien G Luijkx; Maria Th Wijnen-Sponselee; Jos M G A Schols Journal: J Am Med Dir Assoc Date: 2010-03-24 Impact factor: 4.669
Authors: John R Beard; Alana Officer; Islene Araujo de Carvalho; Ritu Sadana; Anne Margriet Pot; Jean-Pierre Michel; Peter Lloyd-Sherlock; JoAnne E Epping-Jordan; G M E E Geeske Peeters; Wahyu Retno Mahanani; Jotheeswaran Amuthavalli Thiyagarajan; Somnath Chatterji Journal: Lancet Date: 2015-10-29 Impact factor: 79.321
Authors: Felicia R Simpson; Nicholas M Pajewski; Kristen M Beavers; Stephen Kritchevsky; Jeanne McCaffery; Barbara J Nicklas; Rena R Wing; Alain Bertoni; Frank Ingram; Daniel Ojeranti; Mark A Espeland Journal: J Gerontol A Biol Sci Med Sci Date: 2021-01-18 Impact factor: 6.591