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Literature DB >> 24733655

Lipid metabolism in Alzheimer's disease.

Abstract

Lipids play crucial roles in cell signaling and various physiological processes, especially in the brain. Impaired lipid metabolism in the brain has been implicated in neurodegenerative diseases, such as Alzheimer's disease (AD), and other central nervous system insults. The brain contains thousands of lipid species, but the complex lipid compositional diversity and the function of each of lipid species are currently poorly understood. This review integrates current knowledge about major lipid changes with the molecular mechanisms that underlie AD pathogenesis.

Entities: Chemical Disease

Mesh：

Year: 2014 PMID： 24733655 PMCID： PMC5562656 DOI： 10.1007/s12264-013-1410-3

Source DB: PubMed Journal: Neurosci Bull ISSN： 1995-8218 Impact factor: 5.203

172 in total

1. Plasma apolipoprotein E and Alzheimer disease risk: the AIBL study of aging.

Authors: V B Gupta; S M Laws; V L Villemagne; D Ames; A I Bush; K A Ellis; J K Lui; C Masters; C C Rowe; C Szoeke; K Taddei; R N Martins
Journal: Neurology Date: 2011-03-22 Impact factor: 9.910

2. Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis.

Authors: H Satoi; H Tomimoto; R Ohtani; T Kitano; T Kondo; M Watanabe; N Oka; I Akiguchi; S Furuya; Y Hirabayashi; T Okazaki
Journal: Neuroscience Date: 2005 Impact factor: 3.590

Review 3. Cellular lipidomics.

Authors: Gerrit van Meer
Journal: EMBO J Date: 2005-09-01 Impact factor: 11.598

Review 4. Lipid signaling in neural plasticity, brain repair, and neuroprotection.

Authors: Nicolas G Bazan
Journal: Mol Neurobiol Date: 2005-08 Impact factor: 5.590

5. Fatty acid composition of frontal, temporal and parietal neocortex in the normal human brain and in Alzheimer's disease.

Authors: Thomas Fraser; Hannah Tayler; Seth Love
Journal: Neurochem Res Date: 2009-11-11 Impact factor: 3.996

6. Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats.

Authors: J Poirier; A Baccichet; D Dea; S Gauthier
Journal: Neuroscience Date: 1993-07 Impact factor: 3.590

7. Decreased lysophosphatidylcholine/phosphatidylcholine ratio in cerebrospinal fluid in Alzheimer's disease.

Authors: C Mulder; L-O Wahlund; T Teerlink; M Blomberg; R Veerhuis; G J van Kamp; P Scheltens; P G Scheffer
Journal: J Neural Transm (Vienna) Date: 2003-08 Impact factor: 3.575

8. Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease.

Authors: T Gomez-Isla; H L West; G W Rebeck; S D Harr; J H Growdon; J J Locascio; T T Perls; L A Lipsitz; B T Hyman
Journal: Ann Neurol Date: 1996-01 Impact factor: 10.422

9. Cholesterol-promoted synaptogenesis requires the conversion of cholesterol to estradiol in the hippocampus.

Authors: Lars Fester; Lepu Zhou; Andrea Bütow; Cornelia Huber; Richard von Lossow; Janine Prange-Kiel; Hubertus Jarry; Gabriele M Rune
Journal: Hippocampus Date: 2009-08 Impact factor: 3.899

10. Role of phosphatidylinositol(4,5)bisphosphate organization in membrane transport by the Unc104 kinesin motor.

Authors: Dieter R Klopfenstein; Michio Tomishige; Nico Stuurman; Ronald D Vale
Journal: Cell Date: 2002-05-03 Impact factor: 41.582

31 in total

1. Alzheimer's disease: from molecule to clinic.

Authors: Jian-Zhi Wang
Journal: Neurosci Bull Date: 2014-04 Impact factor: 5.203

2. N2L, a novel lipoic acid-niacin dimer protects HT22 cells against β-amyloid peptide-induced damage through attenuating apoptosis.

Authors: Rikang Wang; Lang Zhang; Rifang Liao; Qian Li; Rongbiao Pi; Xiaobo Yang
Journal: Metab Brain Dis Date: 2019-09-02 Impact factor: 3.584

3. Temporal phenotyping for transitional disease progress: An application to epilepsy and Alzheimer's disease.

Authors: Yejin Kim; Samden Lhatoo; Guo-Qiang Zhang; Luyao Chen; Xiaoqian Jiang
Journal: J Biomed Inform Date: 2020-06-18 Impact factor: 6.317

Review 4. Lipidome Abnormalities and Cardiovascular Disease Risk in HIV Infection.

Authors: Emily Bowman; Nicholas T Funderburg
Journal: Curr HIV/AIDS Rep Date: 2019-06 Impact factor: 5.071

5. Inter- and intra-chromosomal modulators of the APOE ɛ2 and ɛ4 effects on the Alzheimer's disease risk.

Authors: Alireza Nazarian; Ian Philipp; Irina Culminskaya; Liang He; Alexander M Kulminski
Journal: Geroscience Date: 2022-07-09 Impact factor: 7.713

6. Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.

Authors: Alireza Nazarian; Konstantin G Arbeev; Arseniy P Yashkin; Alexander M Kulminski
Journal: Geroscience Date: 2019-05-05 Impact factor: 7.713

Review 7. Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?

Authors: Si-Qi Du; Xue-Rui Wang; Ling-Yong Xiao; Jian-Feng Tu; Wen Zhu; Tian He; Cun-Zhi Liu
Journal: Mol Neurobiol Date: 2016-05-20 Impact factor: 5.590

Review 8. Alternative mitochondrial electron transfer for the treatment of neurodegenerative diseases and cancers: Methylene blue connects the dots.

Authors: Shao-Hua Yang; Wenjun Li; Nathalie Sumien; Michael Forster; James W Simpkins; Ran Liu
Journal: Prog Neurobiol Date: 2015-11-18 Impact factor: 11.685

Review 9. The Potential of 'Omics to Link Lipid Metabolism and Genetic and Comorbidity Risk Factors of Alzheimer's Disease in African Americans.

Authors: Kaitlyn E Stepler; Renã A S Robinson
Journal: Adv Exp Med Biol Date: 2019 Impact factor: 2.622

10. Evaluating a targeted multiple reaction monitoring approach to global untargeted lipidomic analyses of human plasma.

Authors: Mostafa J Khan; Simona G Codreanu; Sandeep Goyal; Phillip A Wages; Santosh K K Gorti; Mackenzie J Pearson; Isabel Uribe; Stacy D Sherrod; John A McLean; Ned A Porter; Renã A S Robinson
Journal: Rapid Commun Mass Spectrom Date: 2020-11-30 Impact factor: 2.586