Literature DB >> 24733560

Immune escape of γ-herpesviruses from adaptive immunity.

Zhuting Hu1, Edward J Usherwood.   

Abstract

Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV) are two γ-herpesviruses identified in humans and are strongly associated with the development of malignancies. Murine γ-herpesvirus (MHV-68) is a naturally occurring rodent pathogen, representing a unique experimental model for dissecting γ-herpesvirus infection and the immune response. These γ-herpesviruses actively antagonize the innate and adaptive antiviral responses, thereby efficiently establishing latent or persistent infections and even promoting development of malignancies. In this review, we summarize immune evasion strategies of γ-herpesviruses. These include suppression of MHC-I-restricted and MHC-II-restricted antigen presentation, impairment of dendritic cell functions, downregulation of costimulatory molecules, activation of virus-specific regulatory T cells, and induction of inhibitory cytokines. There is a focus on how both γ-herpesvirus-derived and host-derived immunomodulators interfere with adaptive antiviral immunity. Understanding immune-evasive mechanisms is essential for developing future immunotherapies against EBV-driven and KSHV-driven tumors.
Copyright © 2014 John Wiley & Sons, Ltd.

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Mesh：

Year:  2014        PMID： 24733560      PMCID： PMC4198523          DOI： 10.1002/rmv.1791

Source DB:  PubMed          Journal:  Rev Med Virol        ISSN： 1052-9276            Impact factor:   6.989


  153 in total

1.  Downregulation of major histocompatibility complex class I molecules by Kaposi's sarcoma-associated herpesvirus K3 and K5 proteins.

Authors:  S Ishido; C Wang; B S Lee; G B Cohen; J U Jung
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

2.  Epstein-Barr virus inhibits the development of dendritic cells by promoting apoptosis of their monocyte precursors in the presence of granulocyte macrophage-colony-stimulating factor and interleukin-4.

Authors:  LiQi Li; Daorong Liu; Lindsey Hutt-Fletcher; Andrew Morgan; Maria G Masucci; Victor Levitsky
Journal:  Blood       Date:  2002-05-15       Impact factor: 22.113

Review 3.  Persistence of the Epstein-Barr virus and the origins of associated lymphomas.

Authors:  David A Thorley-Lawson; Andrew Gross
Journal:  N Engl J Med       Date:  2004-03-25       Impact factor: 91.245

4.  Epstein-Barr virus gp42 is posttranslationally modified to produce soluble gp42 that mediates HLA class II immune evasion.

Authors:  Maaike E Ressing; Daphne van Leeuwen; Frank A W Verreck; Sinéad Keating; Raquel Gomez; Kees L M C Franken; Tom H M Ottenhoff; Melanie Spriggs; Ton N Schumacher; Lindsey M Hutt-Fletcher; Martin Rowe; Emmanuel J H J Wiertz
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

5.  Loss of EBNA1-specific memory CD4+ and CD8+ T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma.

Authors:  Erwan Piriou; Karel van Dort; Nening M Nanlohy; Marinus H J van Oers; Frank Miedema; Debbie van Baarle
Journal:  Blood       Date:  2005-07-12       Impact factor: 22.113

6.  Nucleotide sequence of the Kaposi sarcoma-associated herpesvirus (HHV8).

Authors:  J J Russo; R A Bohenzky; M C Chien; J Chen; M Yan; D Maddalena; J P Parry; D Peruzzi; I S Edelman; Y Chang; P S Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

7.  Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI.

Authors:  K W Moore; P Vieira; D F Fiorentino; M L Trounstine; T A Khan; T R Mosmann
Journal:  Science       Date:  1990-06-08       Impact factor: 47.728

8.  Nuclear location of an endogenously expressed antigen, EBNA1, restricts access to macroautophagy and the range of CD4 epitope display.

Authors:  Carol S Leung; Tracey A Haigh; Laura K Mackay; Alan B Rickinson; Graham S Taylor
Journal:  Proc Natl Acad Sci U S A       Date:  2010-01-19       Impact factor: 11.205

9.  Lung epithelial cells are a major site of murine gammaherpesvirus persistence.

Authors:  J P Stewart; E J Usherwood; A Ross; H Dyson; T Nash
Journal:  J Exp Med       Date:  1998-06-15       Impact factor: 14.307

10.  The Epstein-Barr virus G-protein-coupled receptor contributes to immune evasion by targeting MHC class I molecules for degradation.

Authors:  Jianmin Zuo; Andrew Currin; Bryan D Griffin; Claire Shannon-Lowe; Wendy A Thomas; Maaike E Ressing; Emmanuel J H J Wiertz; Martin Rowe
Journal:  PLoS Pathog       Date:  2009-01-02       Impact factor: 6.823
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  19 in total

1.  Functional heterogeneity in the CD4+ T cell response to murine γ-herpesvirus 68.

Authors:  Zhuting Hu; Marcia A Blackman; Kenneth M Kaye; Edward J Usherwood
Journal:  J Immunol       Date:  2015-02-06       Impact factor: 5.422

2.  Type I interferon signaling enhances CD8+ T cell effector function and differentiation during murine gammaherpesvirus 68 infection.

Authors:  Ryan N Jennings; Jason M Grayson; Erik S Barton
Journal:  J Virol       Date:  2014-09-24       Impact factor: 5.103

3.  Kaposi's Sarcoma-Associated Herpesvirus Infection of Neurons in HIV-Positive Patients.

Authors:  For Yue Tso; Ashley Sawyer; Eun Hee Kwon; Victor Mudenda; Dianne Langford; You Zhou; John West; Charles Wood
Journal:  J Infect Dis       Date:  2017-06-15       Impact factor: 5.226

4.  An easily transfectable cell line that produces an infectious reporter virus for routine and robust quantitation of Kaposi's sarcoma-associated herpesvirus reactivation.

Authors:  Jennifer L DeCotiis; Noelle C Ortiz; Brian A Vega; David M Lukac
Journal:  J Virol Methods       Date:  2017-06-08       Impact factor: 2.014

5.  Regulatory T Cell Effect on CD8+ T Cell Responses to Human Herpesvirus 8 Infection and Development of Kaposi's Sarcoma.

Authors:  Lauren M Lepone; Giovanna Rappocciolo; Paolo A Piazza; Diana M Campbell; Frank J Jenkins; Charles R Rinaldo
Journal:  AIDS Res Hum Retroviruses       Date:  2017-03-02       Impact factor: 2.205

Review 6.  Therapeutic cancer vaccines.

Authors:  Cornelis J M Melief; Thorbald van Hall; Ramon Arens; Ferry Ossendorp; Sjoerd H van der Burg
Journal:  J Clin Invest       Date:  2015-07-27       Impact factor: 14.808

7.  BZLF1 Attenuates Transmission of Inflammatory Paracrine Senescence in Epstein-Barr Virus-Infected Cells by Downregulating Tumor Necrosis Factor Alpha.

Authors:  Xubing Long; Yuqing Li; Mengtian Yang; Lu Huang; Weijie Gong; Ersheng Kuang
Journal:  J Virol       Date:  2016-08-12       Impact factor: 5.103

8.  Constitutive Activation of Interleukin-13/STAT6 Contributes to Kaposi's Sarcoma-Associated Herpesvirus-Related Primary Effusion Lymphoma Cell Proliferation and Survival.

Authors:  Chong Wang; Caixia Zhu; Fang Wei; Liming Zhang; Xiaohui Mo; Yanling Feng; Jianqing Xu; Zhenghong Yuan; Erle Robertson; Qiliang Cai
Journal:  J Virol       Date:  2015-08-05       Impact factor: 5.103

Review 9.  Interference with the Autophagic Process as a Viral Strategy to Escape from the Immune Control: Lesson from Gamma Herpesviruses.

Authors:  Roberta Santarelli; Marisa Granato; Alberto Faggioni; Mara Cirone
Journal:  J Immunol Res       Date:  2015-05-18       Impact factor: 4.818

Review 10.  Viral Evasion of Natural Killer Cell Activation.

Authors:  Yi Ma; Xiaojuan Li; Ersheng Kuang
Journal:  Viruses       Date:  2016-04-12       Impact factor: 5.048
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