Literature DB >> 24733470

Multiplex PCR for identification of two capsular types in epidemic KPC-producing Klebsiella pneumoniae sequence type 258 strains.

Liang Chen1, Kalyan D Chavda1, Jacqueline Findlay2, Gisele Peirano3, Katie Hopkins2, Johann D D Pitout4, Robert A Bonomo5, Neil Woodford2, Frank R DeLeo6, Barry N Kreiswirth7.   

Abstract

We developed a multiplex PCR assay capable of identifying two capsular polysaccharide synthesis sequence types (sequence type 258 [ST258] cps-1 and cps-2) in epidemic Klebsiella pneumoniae ST258 strains. The assay performed with excellent sensitivity (100%) and specificity (100%) for identifying cps types in 60 ST258 K. pneumoniae sequenced isolates. The screening of 419 ST258 clonal isolates revealed a significant association between cps type and K. pneumoniae carbapenemase (KPC) variant: cps-1 is largely associated with KPC-2, while cps-2 is primarily associated with KPC-3.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24733470      PMCID： PMC4068549          DOI： 10.1128/AAC.02673-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Molecular dissection of the evolution of carbapenem-resistant multilocus sequence type 258 Klebsiella pneumoniae.

Authors:  Frank R Deleo; Liang Chen; Stephen F Porcella; Craig A Martens; Scott D Kobayashi; Adeline R Porter; Kalyan D Chavda; Michael R Jacobs; Barun Mathema; Randall J Olsen; Robert A Bonomo; James M Musser; Barry N Kreiswirth
Journal:  Proc Natl Acad Sci U S A       Date:  2014-03-17       Impact factor: 11.205

2.  Multiplex real-time PCR assay for detection and classification of Klebsiella pneumoniae carbapenemase gene (bla KPC) variants.

Authors:  Liang Chen; José R Mediavilla; Andrea Endimiani; Marnie E Rosenthal; Yanan Zhao; Robert A Bonomo; Barry N Kreiswirth
Journal:  J Clin Microbiol       Date:  2010-12-01       Impact factor: 5.948

3.  Multiplex real-time PCR for detection of an epidemic KPC-producing Klebsiella pneumoniae ST258 clone.

Authors:  Liang Chen; Kalyan D Chavda; José R Mediavilla; Yanan Zhao; Henry S Fraimow; Stephen G Jenkins; Michael H Levi; Tao Hong; Albert D Rojtman; Christine C Ginocchio; Robert A Bonomo; Barry N Kreiswirth
Journal:  Antimicrob Agents Chemother       Date:  2012-03-26       Impact factor: 5.191

Review 4.  Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions.

Authors:  L S Tzouvelekis; A Markogiannakis; M Psichogiou; P T Tassios; G L Daikos
Journal:  Clin Microbiol Rev       Date:  2012-10       Impact factor: 26.132

5.  Surveillance and molecular epidemiology of Klebsiella pneumoniae isolates that produce carbapenemases: first report of OXA-48-like enzymes in North America.

Authors:  Christine Lascols; Gisele Peirano; Meredith Hackel; Kevin B Laupland; Johann D D Pitout
Journal:  Antimicrob Agents Chemother       Date:  2012-10-15       Impact factor: 5.191

Review 6.  Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.

Authors:  L Silvia Munoz-Price; Laurent Poirel; Robert A Bonomo; Mitchell J Schwaber; George L Daikos; Martin Cormican; Giuseppe Cornaglia; Javier Garau; Marek Gniadkowski; Mary K Hayden; Karthikeyan Kumarasamy; David M Livermore; Juan J Maya; Patrice Nordmann; Jean B Patel; David L Paterson; Johann Pitout; Maria Virginia Villegas; Hui Wang; Neil Woodford; John P Quinn
Journal:  Lancet Infect Dis       Date:  2013-09       Impact factor: 25.071

7.  Rapid real-time PCR assays for detection of Klebsiella pneumoniae with the rmpA or magA genes associated with the hypermucoviscosity phenotype: screening of nonhuman primates.

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8.  Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13 reveals remarkable genome plasticity and a wide repertoire of virulence and resistance mechanisms.

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Journal:  BMC Genomics       Date:  2014-01-22       Impact factor: 3.969

9.  Pyrosequencing-based analysis reveals a novel capsular gene cluster in a KPC-producing Klebsiella pneumoniae clinical isolate identified in Brazil.

Authors:  Pablo Ivan Pereira Ramos; Renata Cristina Picão; Eliana Carolina Vespero; Marsileni Pelisson; Luiz Fernando Goda Zuleta; Luiz Gonzaga P Almeida; Alexandra L Gerber; Ana Tereza R Vasconcelos; Ana Cristina Gales; Marisa Fabiana Nicolás
Journal:  BMC Microbiol       Date:  2012-08-11       Impact factor: 3.605

10.  "Stormy waters ahead": global emergence of carbapenemases.

Authors:  Gopi Patel; Robert A Bonomo
Journal:  Front Microbiol       Date:  2013-03-14       Impact factor: 5.640
  10 in total
  18 in total

1.  Re-evaluating the potential of immunoprophylaxis and/or immunotherapy for infections caused by multidrug resistant Klebsiella pneumoniae.

Authors:  Scott D Kobayashi; Frank R DeLeo
Journal:  Future Microbiol       Date:  2018-09-26       Impact factor: 3.165

2.  Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks.

Authors:  Gustavo C Cerqueira; Ashlee M Earl; Christoph M Ernst; Yonatan H Grad; John P Dekker; Michael Feldgarden; Sinéad B Chapman; João L Reis-Cunha; Terrance P Shea; Sarah Young; Qiandong Zeng; Mary L Delaney; Diane Kim; Ellena M Peterson; Thomas F O'Brien; Mary Jane Ferraro; David C Hooper; Susan S Huang; James E Kirby; Andrew B Onderdonk; Bruce W Birren; Deborah T Hung; Lisa A Cosimi; Jennifer R Wortman; Cheryl I Murphy; William P Hanage
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-17       Impact factor: 11.205

3.  Genomic and Biochemical Characterization of Acinetobacter Podophage Petty Reveals a Novel Lysis Mechanism and Tail-Associated Depolymerase Activity.

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Review 4.  The role of epidemic resistance plasmids and international high-risk clones in the spread of multidrug-resistant Enterobacteriaceae.

Authors:  Amy J Mathers; Gisele Peirano; Johann D D Pitout
Journal:  Clin Microbiol Rev       Date:  2015-07       Impact factor: 26.132

5.  Multiplex PCR Analysis for Rapid Detection of Klebsiella pneumoniae Carbapenem-Resistant (Sequence Type 258 [ST258] and ST11) and Hypervirulent (ST23, ST65, ST86, and ST375) Strains.

Authors:  Fangyou Yu; Jingnan Lv; Siqiang Niu; Hong Du; Yi-Wei Tang; Johann D D Pitout; Robert A Bonomo; Barry N Kreiswirth; Liang Chen
Journal:  J Clin Microbiol       Date:  2018-08-27       Impact factor: 5.948

6.  Identification of capsular types in carbapenem-resistant Klebsiella pneumoniae strains by wzc sequencing and implications for capsule depolymerase treatment.

Authors:  Yi-Jiun Pan; Tzu-Lung Lin; Yi-Tsung Lin; Po-An Su; Chun-Tang Chen; Pei-Fang Hsieh; Chun-Ru Hsu; Ching-Ching Chen; Yu-Chia Hsieh; Jin-Town Wang
Journal:  Antimicrob Agents Chemother       Date:  2014-12-01       Impact factor: 5.191

7.  Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II.

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8.  Multicenter Clinical and Molecular Epidemiological Analysis of Bacteremia Due to Carbapenem-Resistant Enterobacteriaceae (CRE) in the CRE Epicenter of the United States.

Authors:  Michael J Satlin; Liang Chen; Gopi Patel; Angela Gomez-Simmonds; Gregory Weston; Angela C Kim; Susan K Seo; Marnie E Rosenthal; Steven J Sperber; Stephen G Jenkins; Camille L Hamula; Anne-Catrin Uhlemann; Michael H Levi; Bettina C Fries; Yi-Wei Tang; Stefan Juretschko; Albert D Rojtman; Tao Hong; Barun Mathema; Michael R Jacobs; Thomas J Walsh; Robert A Bonomo; Barry N Kreiswirth
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9.  Survival of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 258 in Human Blood.

Authors:  Frank R DeLeo; Scott D Kobayashi; Adeline R Porter; Brett Freedman; David W Dorward; Liang Chen; Barry N Kreiswirth
Journal:  Antimicrob Agents Chemother       Date:  2017-03-24       Impact factor: 5.191

10.  A Two-Year Surveillance in Five Colombian Tertiary Care Hospitals Reveals High Frequency of Non-CG258 Clones of Carbapenem-Resistant Klebsiella pneumoniae with Distinct Clinical Characteristics.

Authors:  Ana M Ocampo; Liang Chen; Astrid V Cienfuegos; Gustavo Roncancio; Kalyan D Chavda; Barry N Kreiswirth; J Natalia Jiménez
Journal:  Antimicrob Agents Chemother       Date:  2015-10-26       Impact factor: 5.191
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