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Literature DB >> 24732364

Emerging inhalation aerosol devices and strategies: where are we headed?

Qi Tony Zhou¹, Patricia Tang¹, Sharon Shui Yee Leung¹, John Gar Yan Chan², Hak-Kim Chan³.

Abstract

Novel inhaled therapeutics including antibiotics, vaccines and anti-hypertensives, have led to innovations in designing suitable delivery systems. These emerging design technologies are in urgent demand to ensure high aerosolisation performance, consistent efficacy and satisfactory patient adherence. Recent vibrating-mesh and software technologies have resulted in nebulisers that have remarkably accurate dosing and portability. Alternatively, dry powder inhalers (DPIs) have become highly favourable for delivering high-dose and single-dose drugs with the aid of advanced particle engineering. In contrast, innovations are needed to overcome the technical constrains in drug-propellant incompatibility and delivering high-dose drugs with pressurised metered dose inhalers (pMDIs). This review discusses recent and emerging trends in pulmonary drug delivery systems.

Entities: Disease Species

Keywords: Computational modelling; Dry powder inhaler; Inhalation therapy; Nebuliser; Particle engineering; Patient adherence; Pressurised metered dose inhaler; Pulmonary drug delivery

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Year: 2014 PMID： 24732364 DOI： 10.1016/j.addr.2014.03.006

Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470

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Cited

42 in total

1. Dry Lung as a Physical Model in Studies of Aerosol Deposition.

Authors: Victor N Morozov; Igor L Kanev
Journal: Lung Date: 2015-08-13 Impact factor: 2.584

2. Understanding the Impacts of Surface Compositions on the In-Vitro Dissolution and Aerosolization of Co-Spray-Dried Composite Powder Formulations for Inhalation.

Authors: Sharad Mangal; Rongkun Xu; Heejun Park; Dmitry Zemlyanov; Nivedita Shetty; Yu-Wei Lin; David Morton; Hak-Kim Chan; Jian Li; Qi Tony Zhou
Journal: Pharm Res Date: 2018-11-07 Impact factor: 4.200

3. Understanding the Different Effects of Inhaler Design on the Aerosol Performance of Drug-Only and Carrier-Based DPI Formulations. Part 1: Grid Structure.

Authors: Cassandra Ming Shan Leung; Zhenbo Tong; Qi Tony Zhou; John Gar Yan Chan; Patricia Tang; Siping Sun; Runyu Yang; Hak-Kim Chan
Journal: AAPS J Date: 2016-05-09 Impact factor: 4.009

Review 4. Clinical pharmacokinetics of inhaled antimicrobials.

Authors: Chris Stockmann; Jessica K Roberts; Venkata K Yellepeddi; Catherine M T Sherwin
Journal: Clin Pharmacokinet Date: 2015-05 Impact factor: 6.447

5. SPECT-CT Comparison of Lung Deposition using a System combining a Vibrating-mesh Nebulizer with a Valved Holding Chamber and a Conventional Jet Nebulizer: a Randomized Cross-over Study.

Authors: Jonathan Dugernier; Michel Hesse; Rita Vanbever; Virginie Depoortere; Jean Roeseler; Jean-Bernard Michotte; Pierre-François Laterre; François Jamar; Gregory Reychler
Journal: Pharm Res Date: 2016-11-07 Impact factor: 4.200

Review 6. Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunities.

Authors: Sharad Mangal; Wei Gao; Tonglei Li; Qi Tony Zhou
Journal: Acta Pharmacol Sin Date: 2017-05-01 Impact factor: 6.150

10. Physico-Chemical Properties, Aerosolization and Dissolution of Co-Spray Dried Azithromycin Particles with L-Leucine for Inhalation.

Authors: Sharad Mangal; Haichen Nie; Rongkun Xu; Rui Guo; Alex Cavallaro; Dmitry Zemlyanov; Qi Tony Zhou
Journal: Pharm Res Date: 2018-01-08 Impact factor: 4.200