Paul Mazaris1, Xin Hong1, David Altshuler2, Lonni Schultz3, Laila M Poisson3, Rajan Jain4, Tom Mikkelsen1, Mark Rosenblum1, Steven Kalkanis5. 1. Departments of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Health System, 2799 West Grand Boulevard, Detroit 48202, USA. 2. Wayne State University School of Medicine, 1313 Scott Hall, Detroit 48201, USA. 3. Public Health Sciences, Henry Ford Health System, 2799 West Grand Boulevard, Detroit 48202, USA. 4. Departments of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Health System, 2799 West Grand Boulevard, Detroit 48202, USA; Radiology, Henry Ford Health System, 2799 West Grand Boulevard, Detroit 48202, USA. 5. Departments of Neurosurgery, Hermelin Brain Tumor Center, Henry Ford Health System, 2799 West Grand Boulevard, Detroit 48202, USA. Electronic address: skalkan1@hfhs.org.
Abstract
OBJECTIVE: Glioblastoma (GBM) is a heterogeneous neoplasm with a small percentage of long-term survivors. Despite aggressive surgical resection and advances in radiotherapy and chemotherapy, the median survival for patients with GBM is 12-14 months. Factors associated with a favorable prognosis include young age, high performance status, gross resection >98%, non-eloquent tumor location and O6-methylguanine methyltransferase (MGMT) promoter methylation. We retrospectively analyzed the relationship of clinical, epidemiologic, genetic and molecular characteristics with survival in patients with GBM. METHODS: This retrospective analysis of overall survival looked at the outcomes of 480 patients diagnosed with GBM over 14 years at a single institution. Multivariate analysis was performed examining multiple patient characteristics. RESULTS: Median survival time improved from 11.8 months in patients diagnosed from 1995 to 1999 to 15.9 months in those diagnosed from 2005 to 2008. Factors associated with survivor groups were age, KPS, tumor resection, treatment received and early progression. 18 cancer-related genes were upregulated in short-term survivors and five genes were downregulated in short-term survivors. CONCLUSIONS: Epidemiologic, clinical, and molecular characteristics all contribute to GBM prognosis. Identifying factors associated with survival is important for treatment strategies as well as research for novel therapeutics and technologies. This study demonstrated improved survival for patients over time as well as significant differences among survivor groups.
OBJECTIVE:Glioblastoma (GBM) is a heterogeneous neoplasm with a small percentage of long-term survivors. Despite aggressive surgical resection and advances in radiotherapy and chemotherapy, the median survival for patients with GBM is 12-14 months. Factors associated with a favorable prognosis include young age, high performance status, gross resection >98%, non-eloquent tumor location and O6-methylguanine methyltransferase (MGMT) promoter methylation. We retrospectively analyzed the relationship of clinical, epidemiologic, genetic and molecular characteristics with survival in patients with GBM. METHODS: This retrospective analysis of overall survival looked at the outcomes of 480 patients diagnosed with GBM over 14 years at a single institution. Multivariate analysis was performed examining multiple patient characteristics. RESULTS: Median survival time improved from 11.8 months in patients diagnosed from 1995 to 1999 to 15.9 months in those diagnosed from 2005 to 2008. Factors associated with survivor groups were age, KPS, tumor resection, treatment received and early progression. 18 cancer-related genes were upregulated in short-term survivors and five genes were downregulated in short-term survivors. CONCLUSIONS: Epidemiologic, clinical, and molecular characteristics all contribute to GBM prognosis. Identifying factors associated with survival is important for treatment strategies as well as research for novel therapeutics and technologies. This study demonstrated improved survival for patients over time as well as significant differences among survivor groups.
Authors: Corbin A Rayfield; Fillan Grady; Gustavo De Leon; Russell Rockne; Eduardo Carrasco; Pamela Jackson; Mayur Vora; Sandra K Johnston; Andrea Hawkins-Daarud; Kamala R Clark-Swanson; Scott Whitmire; Mauricio E Gamez; Alyx Porter; Leland Hu; Luis Gonzalez-Cuyar; Bernard Bendok; Sujay Vora; Kristin R Swanson Journal: JCO Clin Cancer Inform Date: 2018-12
Authors: Jad Alshami; Marie-Christine Guiot; Scott Owen; Petr Kavan; Neil Gibson; Flavio Solca; Agnieszka Cseh; David A Reardon; Thierry Muanza Journal: Oncotarget Date: 2015-10-20
Authors: Warren Chang; Whitney B Pope; Robert J Harris; Anthony J Hardy; Kevin Leu; Reema R Mody; Phioanh L Nghiemphu; Albert Lai; Timothy F Cloughesy; Benjamin M Ellingson Journal: Tomography Date: 2015-09