OBJECTIVE: The aim of this study was to explore the clinical role of serum interleukin (IL)-17 in patients with non-small-cell lung cancer (NSCLC). MATERIALS AND METHOD: Serum specimens from 128 patients with NSCLC and 60 healthy controls were collected. The concentrations of IL-17 were measured using enzyme-linked immunosorbent assay. RESULTS: Serum IL-17 levels were higher in the NSCLC group in comparison with the control group (p < 0.01). With a cut-off value of 16 pg/ml, IL-17 showed a good diagnostic performance for NSCLC. Multivariate survival analysis indicated that IL-17 was an independent prognostic factor in NSCLC. CONCLUSION: Measurement of IL-17 might be a useful diagnostic and prognostic value for patients with NSCLC.
OBJECTIVE: The aim of this study was to explore the clinical role of serum interleukin (IL)-17 in patients with non-small-cell lung cancer (NSCLC). MATERIALS AND METHOD: Serum specimens from 128 patients with NSCLC and 60 healthy controls were collected. The concentrations of IL-17 were measured using enzyme-linked immunosorbent assay. RESULTS: Serum IL-17 levels were higher in the NSCLC group in comparison with the control group (p < 0.01). With a cut-off value of 16 pg/ml, IL-17 showed a good diagnostic performance for NSCLC. Multivariate survival analysis indicated that IL-17 was an independent prognostic factor in NSCLC. CONCLUSION: Measurement of IL-17 might be a useful diagnostic and prognostic value for patients with NSCLC.
Authors: Esra A Akbay; Shohei Koyama; Yan Liu; Ruben Dries; Lauren E Bufe; Michael Silkes; Md Maksudul Alam; Dillon M Magee; Robert Jones; Masahisa Jinushi; Meghana Kulkarni; Julian Carretero; Xiaoen Wang; Tiquella Warner-Hatten; Jillian D Cavanaugh; Akio Osa; Atsushi Kumanogoh; Gordon J Freeman; Mark M Awad; David C Christiani; Raphael Bueno; Peter S Hammerman; Glenn Dranoff; Kwok-Kin Wong Journal: J Thorac Oncol Date: 2017-05-06 Impact factor: 15.609
Authors: Laura P Stabile; Mariya Farooqui; Beatriz Kanterewicz; Shira Abberbock; Brenda F Kurland; Brenda Diergaarde; Jill M Siegfried Journal: J Thorac Oncol Date: 2017-12-09 Impact factor: 15.609
Authors: Simone Punt; Jessica M Langenhoff; H Putter; Gert Jan Fleuren; Arko Gorter; Ekaterina S Jordanova Journal: Oncoimmunology Date: 2015-03-06 Impact factor: 8.110