| Literature DB >> 25949881 |
Simone Punt1, Jessica M Langenhoff2, H Putter3, Gert Jan Fleuren1, Arko Gorter1, Ekaterina S Jordanova1.
Abstract
Both IL-17 and Th17 cells have been ascribed tumor promoting as well as tumor suppressing functions. We reviewed the literature on correlations between IL-17 versus Th17 cells and survival in human cancer, following the PRISMA guidelines. Serum, formalin-fixed, paraffin-embedded (FFPE) tissue and peripheral blood samples were most frequently studied. High IL-17 quantities were correlated with poor prognosis, whereas high Th17 cell frequencies were correlated with improved prognosis. Since Th17 cells are a subpopulation of IL-17+ cells and had a different correlation with prognosis than total IL-17, we substantiate that a distinction should be made between Th17 and other IL-17+ cells.Entities:
Keywords: FFPE, formalin-fixed, paraffin-embedded; IL-17; PBMC, peripheral blood mononuclear cells; RORγ, receptor-related orphan receptor gamma; TNM, tumor node metastasis stage; Th17; cancer; survival; tumor microenvironment
Year: 2015 PMID： 25949881 PMCID： PMC4404813 DOI： 10.4161/2162402X.2014.984547
Source DB: PubMed Journal: Oncoimmunology ISSN： 2162-4011 Impact factor: 8.110