PURPOSE: The aim of this study was to examine how transition between normal glucose tolerance, prediabetes and diabetes over a 7 year period is associated with change in health-related quality of life (HRQL) in an elder German population-based cohort. METHODS: We used data from 1,046 participants of the KORA S4/F4 cohort study aged 55-74 years at baseline. Based on an oral glucose tolerance test, prediabetes was defined as impaired fasting glucose and/or impaired glucose tolerance. HRQL was assessed with the SF-12 questionnaire. Using linear regression, we estimated mean change in HRQL over time, depending on glucose status at baseline and follow-up, adjusted by demographic and lifestyle variables. RESULTS: Individuals progressing to prediabetes or diabetes experienced a greater loss in the physical component score than patients with persistent normal glucose tolerance (-2.31 and -7.44 vs. -1.08), but the difference was only significant for subjects converting to diabetes. Subjects with prediabetes at baseline and diabetes at follow-up had a significant loss in mental health compared to subjects with persistent prediabetes. CONCLUSIONS: There is first evidence that worsening of glucose metabolism over time is associated with deteriorating HRQL, however, further and larger longitudinal studies are needed to confirm these findings.
PURPOSE: The aim of this study was to examine how transition between normal glucose tolerance, prediabetes and diabetes over a 7 year period is associated with change in health-related quality of life (HRQL) in an elder German population-based cohort. METHODS: We used data from 1,046 participants of the KORA S4/F4 cohort study aged 55-74 years at baseline. Based on an oral glucose tolerance test, prediabetes was defined as impaired fasting glucose and/or impaired glucose tolerance. HRQL was assessed with the SF-12 questionnaire. Using linear regression, we estimated mean change in HRQL over time, depending on glucose status at baseline and follow-up, adjusted by demographic and lifestyle variables. RESULTS: Individuals progressing to prediabetes or diabetes experienced a greater loss in the physical component score than patients with persistent normal glucose tolerance (-2.31 and -7.44 vs. -1.08), but the difference was only significant for subjects converting to diabetes. Subjects with prediabetes at baseline and diabetes at follow-up had a significant loss in mental health compared to subjects with persistent prediabetes. CONCLUSIONS: There is first evidence that worsening of glucose metabolism over time is associated with deteriorating HRQL, however, further and larger longitudinal studies are needed to confirm these findings.
Authors: B Kowall; W Rathmann; M Heier; R Holle; A Peters; B Thorand; C Herder; K Strassburger; G Giani; C Meisinger Journal: Int J Obes (Lond) Date: 2011-08-23 Impact factor: 5.095
Authors: Robyn J Tapp; David W Dunstan; Pat Phillips; Andrew Tonkin; Paul Z Zimmet; Jonathan E Shaw Journal: Diabetes Res Clin Pract Date: 2006-06-05 Impact factor: 5.602
Authors: M C Adriaanse; J M Dekker; R J Heine; F J Snoek; A J Beekman; C D Stehouwer; L M Bouter; G Nijpels; F Pouwer Journal: Diabet Med Date: 2008-07 Impact factor: 4.359
Authors: Tellervo Seppälä; Ulla Saxen; Hannu Kautiainen; Salme Järvenpää; Päivi E Korhonen Journal: Prim Care Diabetes Date: 2013-04-29 Impact factor: 2.459
Authors: Jian Li; Natalie Riedel; Amira Barrech; Raphael M Herr; Birgit Aust; Kathrin Mörtl; Johannes Siegrist; Harald Gündel; Peter Angerer Journal: Biomed Res Int Date: 2017-10-18 Impact factor: 3.411
Authors: Jannica S Selenius; Niko S Wasenius; Hannu Kautiainen; Minna Salonen; Mikaela von Bonsdorff; Johan G Eriksson Journal: BMJ Open Diabetes Res Care Date: 2020-10
Authors: Luis A Anillo Arrieta; Tania Acosta Vergara; Rafael Tuesca; Sandra Rodríguez Acosta; Karen C Flórez Lozano; Pablo Aschner; Rafael Gabriel; Sandra De La Rosa; Julieth P Nieto Castillo; Noël C Barengo Journal: Health Qual Life Outcomes Date: 2021-12-20 Impact factor: 3.186
Authors: Daniëlle Otten; Ana N Tibubos; Georg Schomerus; Elmar Brähler; Harald Binder; Johannes Kruse; Karl-Heinz Ladwig; Philipp S Wild; Hans J Grabe; Manfred E Beutel Journal: Front Public Health Date: 2021-02-05