| Literature DB >> 24727083 |
Guoxu Ma1, Zhaocui Sun1, Zhonghao Sun1, Jingquan Yuan2, Hua Wei3, Junshan Yang1, Haifeng Wu4, Xudong Xu5.
Abstract
Two new diterpene alkaloids, caesalminines A (1) and B (2), possessing a tetracyclic cassane-type furanoditerpenoid skeleton with γ-lactam ring, were isolated from the seeds of Caesalpinia minax. Their structures were determined by different spectroscopic methods and ECD calculation. The plausible biosynthetic pathway of caesalminines A and B was proposed. The anti-malarial activity of compounds 1 and 2 is presented with IC50 values of 0.42 and 0.79 μM, respectively.Entities:
Keywords: Antimalarial activity; Biosynthetic pathway; Caesalpinia; Diterpene alkaloid
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Year: 2014 PMID： 24727083 DOI： 10.1016/j.fitote.2014.04.001
Source DB: PubMed Journal: Fitoterapia ISSN： 0367-326X Impact factor: 2.882