Xiaowen Liu1, Ole-Petter R Hamnvik2, John P Chamberland3, Michael Petrou4, Huizhi Gong1, Costas A Christophi5, David C Christiani6, Stefanos N Kales7, Christos S Mantzoros8. 1. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA. 2. Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA. 3. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Section of Endocrinology, Boston VA Healthcare System, Boston, MA. 4. Cyprus International Institute for Environmental and Public Health in association with Harvard School of Public Health, Cyprus University of Technology, Limassol, Cyprus. 5. Cyprus International Institute for Environmental and Public Health in association with Harvard School of Public Health, Cyprus University of Technology, Limassol, Cyprus; Department of Environmental Health, Harvard School of Public Health, Boston, MA. 6. Department of Environmental Health, Harvard School of Public Health, Boston, MA. 7. Department of Environmental Health, Harvard School of Public Health, Boston, MA. Electronic address: skales@hsph.harvard.edu. 8. Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA; Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA; Department of Environmental Health, Harvard School of Public Health, Boston, MA; Section of Endocrinology, Boston VA Healthcare System, Boston, MA.
Abstract
OBJECTIVE: To comparatively evaluate traditional liver tests and fetuin A as predictors of cardiometabolic risk, we studied associations between serum alanine transaminase (ALT), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST) and fetuin-A and anthropometric, metabolic, and cardiovascular parameters cross-sectionally at baseline, and prospectively, after 2-years of follow-up. RESEARCH DESIGN AND METHODS: 616 randomly enrolled young healthy participants in the Cyprus Metabolism Study, including all 93 subjects who participated in the follow-up study 2 years after baseline assessment, were included in this study. RESULTS: In the cross-sectional study, serum ALT and GGT were strongly correlated with anthropometric, cardiovascular, and metabolic variables, while serum AST was only correlated with waist circumference and waist-to-hip ratio. Fetuin-A was correlated with anthropometric variables, systolic blood pressure (SBP), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) in the unadjusted model. In the fully adjusted model, both serum ALT and GGT levels remained positively correlated with total and low-density lipoprotein (LDL) cholesterol. GGT levels also remained correlated with triglycerides. ALT levels remained strongly positively correlated with insulin (r=0.17, p<.0001) and HOMA-IR (r=0.16, p=0.0001). Serum fetuin-A levels were no longer significantly correlated with any variables. Prospectively, ALT and GGT were predictors of anthropometric variables and LDL cholesterol, while baseline levels of AST and fetuin-A were not predictors of any variables at 2-year follow-up. CONCLUSIONS: We confirmed associations of ALT and GGT levels but failed to demonstrate an independent association between fetuin-A and cardiometabolic risk factors in young healthy men. Traditional liver tests (LFTs) are thus better than fetuin-A predictors of metabolic risk factors cross-sectionally and prospectively in young healthy adults.
OBJECTIVE: To comparatively evaluate traditional liver tests and fetuin A as predictors of cardiometabolic risk, we studied associations between serum alanine transaminase (ALT), γ-glutamyl transferase (GGT), aspartate aminotransferase (AST) and fetuin-A and anthropometric, metabolic, and cardiovascular parameters cross-sectionally at baseline, and prospectively, after 2-years of follow-up. RESEARCH DESIGN AND METHODS: 616 randomly enrolled young healthy participants in the Cyprus Metabolism Study, including all 93 subjects who participated in the follow-up study 2 years after baseline assessment, were included in this study. RESULTS: In the cross-sectional study, serum ALT and GGT were strongly correlated with anthropometric, cardiovascular, and metabolic variables, while serum AST was only correlated with waist circumference and waist-to-hip ratio. Fetuin-A was correlated with anthropometric variables, systolic blood pressure (SBP), insulin, and homeostasis model of assessment-insulin resistance (HOMA-IR) in the unadjusted model. In the fully adjusted model, both serum ALT and GGT levels remained positively correlated with total and low-density lipoprotein (LDL) cholesterol. GGT levels also remained correlated with triglycerides. ALT levels remained strongly positively correlated with insulin (r=0.17, p<.0001) and HOMA-IR (r=0.16, p=0.0001). Serum fetuin-A levels were no longer significantly correlated with any variables. Prospectively, ALT and GGT were predictors of anthropometric variables and LDL cholesterol, while baseline levels of AST and fetuin-A were not predictors of any variables at 2-year follow-up. CONCLUSIONS: We confirmed associations of ALT and GGT levels but failed to demonstrate an independent association between fetuin-A and cardiometabolic risk factors in young healthy men. Traditional liver tests (LFTs) are thus better than fetuin-A predictors of metabolic risk factors cross-sectionally and prospectively in young healthy adults.
Authors: Joachim H Ix; Christina L Wassel; Alka M Kanaya; Eric Vittinghoff; Karen C Johnson; Annemarie Koster; Jane A Cauley; Tamara B Harris; Steven R Cummings; Michael G Shlipak Journal: JAMA Date: 2008-07-09 Impact factor: 56.272
Authors: Joachim H Ix; Christina L Wassel; Glenn M Chertow; Annemarie Koster; Karen C Johnson; Frances A Tylavsky; Jane A Cauley; Steven R Cummings; Tamara B Harris; Michael G Shlipak Journal: J Clin Endocrinol Metab Date: 2009-10-09 Impact factor: 5.958
Authors: Lili Xia; Fen Dong; Haiying Gong; Guodong Xu; Ke Wang; Fen Liu; Li Pan; Ling Zhang; Yuxiang Yan; Herbert Gaisano; Yan He; Guangliang Shan Journal: Int J Environ Res Public Health Date: 2017-04-07 Impact factor: 3.390
Authors: Mariana R Sato; João A Oshiro Junior; Rachel Ta Machado; Paula C de Souza; Débora L Campos; Fernando R Pavan; Patricia B da Silva; Marlus Chorilli Journal: Drug Des Devel Ther Date: 2017-03-20 Impact factor: 4.162
Authors: Shozab S Ali; Ebenezer T Oni; Michael J Blaha; Emir Veledar; Hamid R Feiz; Theodore Feldman; Arthur S Agatston; Roger S Blumenthal; Raquel D Conceicao; Jose A M Carvalho; Raul D Santos; Khurram Nasir Journal: Nutr Metab (Lond) Date: 2016-05-18 Impact factor: 4.169