Literature DB >> 24723119

Biosynthesis of the antibiotic tropodithietic acid by the marine bacterium Phaeobacter inhibens.

Nelson L Brock1, Alexander Nikolay, Jeroen S Dickschat.   

Abstract

The biosynthesis of tropodithietic acid was investigated using a combinatorial approach of feeding experiments, gene knockouts and bioinformatic analyses. The mechanism of sulfur introduction is distinct from known mechanisms in holomycin, thiomarinol A and gliotoxin biosynthesis.

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Year:  2014        PMID： 24723119     DOI： 10.1039/c4cc01924e

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  25 in total

1.  Biosynthesis of Tropolones in Streptomyces spp.: Interweaving Biosynthesis and Degradation of Phenylacetic Acid and Hydroxylations on the Tropone Ring.

Authors:  Xuefei Chen; Min Xu; Jin Lü; Jianguo Xu; Yemin Wang; Shuangjun Lin; Zixin Deng; Meifeng Tao
Journal:  Appl Environ Microbiol       Date:  2018-05-31       Impact factor: 4.792

2.  Influence of Iron on Production of the Antibacterial Compound Tropodithietic Acid and Its Noninhibitory Analog in Phaeobacter inhibens.

Authors:  Paul W D'Alvise; Christopher B W Phippen; Kristian F Nielsen; Lone Gram
Journal:  Appl Environ Microbiol       Date:  2015-10-30       Impact factor: 4.792

3.  Amino Acid and Sugar Catabolism in the Marine Bacterium Phaeobacter inhibens DSM 17395 from an Energetic Viewpoint.

Authors:  Daniel Wünsch; Kathleen Trautwein; Sabine Scheve; Christina Hinrichs; Christoph Feenders; Bernd Blasius; Dietmar Schomburg; Ralf Rabus
Journal:  Appl Environ Microbiol       Date:  2019-11-27       Impact factor: 4.792

4.  The marine bacterium Phaeobacter inhibens secures external ammonium by rapid buildup of intracellular nitrogen stocks.

Authors:  Kathleen Trautwein; Michael Hensler; Katharina Wiegmann; Ekaterina Skorubskaya; Lars Wöhlbrand; Daniel Wünsch; Christina Hinrichs; Christoph Feenders; Constanze Müller; Kristina Schell; Hanna Ruppersberg; Jannes Vagts; Sebastian Koßmehl; Alexander Steinbüchel; Philippe Schmidt-Kopplin; Heinz Wilkes; Helmut Hillebrand; Bernd Blasius; Dietmar Schomburg; Ralf Rabus
Journal:  FEMS Microbiol Ecol       Date:  2018-10-01       Impact factor: 4.194

5.  Two Flavoenzymes Catalyze the Post-Translational Generation of 5-Chlorotryptophan and 2-Aminovinyl-Cysteine during NAI-107 Biosynthesis.

Authors:  Manuel A Ortega; Dillon P Cogan; Subha Mukherjee; Neha Garg; Bo Li; Gabrielle N Thibodeaux; Sonia I Maffioli; Stefano Donadio; Margherita Sosio; Jerome Escano; Leif Smith; Satish K Nair; Wilfred A van der Donk
Journal:  ACS Chem Biol       Date:  2017-01-13       Impact factor: 5.100

6.  Impact of Quorum Sensing and Tropodithietic Acid Production on the Exometabolome of Phaeobacter inhibens.

Authors:  Sujatha Srinivas; Martine Berger; Thorsten Brinkhoff; Jutta Niggemann
Journal:  Front Microbiol       Date:  2022-06-21       Impact factor: 6.064

7.  Coupled Biosynthesis of Volatiles and Salinosporamide A in Salinispora tropica.

Authors:  Ulrike Groenhagen; Ana Ligia Leandrini De Oliveira; Elisha Fielding; Bradley S Moore; Stefan Schulz
Journal:  Chembiochem       Date:  2016-09-06       Impact factor: 3.164

8.  Biosynthesis of Ditropolonyl Sulfide, an Antibacterial Compound Produced by Burkholderia cepacia Complex Strain R-12632.

Authors:  Eliza Depoorter; Tom Coenye; Peter Vandamme
Journal:  Appl Environ Microbiol       Date:  2021-09-15       Impact factor: 4.792

Review 9.  The importance of mass spectrometric dereplication in fungal secondary metabolite analysis.

Authors:  Kristian F Nielsen; Thomas O Larsen
Journal:  Front Microbiol       Date:  2015-02-17       Impact factor: 5.640

10.  Synthesis and bioactivity of analogues of the marine antibiotic tropodithietic acid.

Authors:  Patrick Rabe; Tim A Klapschinski; Nelson L Brock; Christian A Citron; Paul D'Alvise; Lone Gram; Jeroen S Dickschat
Journal:  Beilstein J Org Chem       Date:  2014-08-06       Impact factor: 2.883
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