Literature DB >> 24722429

IGF binding proteins in cancer: mechanistic and clinical insights.

Robert C Baxter1.   

Abstract

The six members of the family of insulin-like growth factor (IGF) binding proteins (IGFBPs) were originally characterized as passive reservoirs of circulating IGFs, but they are now understood to have many actions beyond their endocrine role in IGF transport. IGFBPs also function in the pericellular and intracellular compartments to regulate cell growth and survival - they interact with many proteins, in addition to their canonical ligands IGF-I and IGF-II. Intranuclear roles of IGFBPs in transcriptional regulation, induction of apoptosis and DNA damage repair point to their intimate involvement in tumour development, progression and resistance to treatment. Tissue or circulating IGFBPs might also be useful as prognostic biomarkers.

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Year:  2014        PMID： 24722429     DOI： 10.1038/nrc3720

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  216 in total

1.  Tumor-associated retinal astrocytes promote retinoblastoma cell proliferation through production of IGFBP-5.

Authors:  Xiaoliang L Xu; Thomas C Lee; Nneka Offor; Christine Cheng; Aihong Liu; Yuqiang Fang; Suresh C Jhanwar; David H Abramson; David Cobrinik
Journal:  Am J Pathol       Date:  2010-05-27       Impact factor: 4.307

2.  Plasminogen activator inhibitor 1--insulin-like growth factor binding protein 3 cascade regulates stress-induced senescence.

Authors:  David J Elzi; Yanlai Lai; Meihua Song; Kevin Hakala; Susan T Weintraub; Yuzuru Shiio
Journal:  Proc Natl Acad Sci U S A       Date:  2012-07-09       Impact factor: 11.205

3.  Circulating binding proteins for the insulinlike growth factors.

Authors:  R C Baxter
Journal:  Trends Endocrinol Metab       Date:  1993-04       Impact factor: 12.015

4.  EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment.

Authors:  Gianmaria Liccardi; John A Hartley; Daniel Hochhauser
Journal:  Cancer Res       Date:  2011-01-25       Impact factor: 12.701

Review 5.  Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.

Authors:  S Rajaram; D J Baylink; S Mohan
Journal:  Endocr Rev       Date:  1997-12       Impact factor: 19.871

6.  Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding.

Authors:  Zhihe Kuang; Shenggen Yao; Kerrie A McNeil; Julian A Thompson; Leon A Bach; Briony E Forbes; John C Wallace; Raymond S Norton
Journal:  Biochemistry       Date:  2007-11-07       Impact factor: 3.162

7.  Targeted deletion of hepatic Igf1 in TRAMP mice leads to dramatic alterations in the circulating insulin-like growth factor axis but does not reduce tumor progression.

Authors:  Makoto Anzo; Laura J Cobb; David L Hwang; Hemal Mehta; Jonathan W Said; Shoshana Yakar; Derek LeRoith; Pinchas Cohen
Journal:  Cancer Res       Date:  2008-05-01       Impact factor: 12.701

8.  Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization.

Authors:  Kuk-Wha Lee; Bingrong Liu; Liqun Ma; Heju Li; Peter Bang; H Phillip Koeffler; Pinchas Cohen
Journal:  J Biol Chem       Date:  2003-10-22       Impact factor: 5.157

9.  IGFBP-3 activates TGF-beta receptors and directly inhibits growth in human intestinal smooth muscle cells.

Authors:  John F Kuemmerle; Karnam S Murthy; Jennifer G Bowers
Journal:  Am J Physiol Gastrointest Liver Physiol       Date:  2004-06-03       Impact factor: 4.052

10.  Insulin-like growth factor binding proteins: a structural perspective.

Authors:  Briony E Forbes; Peter McCarthy; Raymond S Norton
Journal:  Front Endocrinol (Lausanne)       Date:  2012-03-02       Impact factor: 5.555
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  213 in total

1.  Neuro-oncology: a step towards clinical blood biomarkers of glioblastoma.

Authors:  Matthias Preusser
Journal:  Nat Rev Neurol       Date:  2014-11-04       Impact factor: 42.937

2.  Mesenchymal stem cells gene signature in high-risk myeloma bone marrow linked to suppression of distinct IGFBP2-expressing small adipocytes.

Authors:  Syed J Mehdi; Sarah K Johnson; Joshua Epstein; Maurizio Zangari; Pingping Qu; Antje Hoering; Frits van Rhee; Carolina Schinke; Sharmilan Thanendrarajan; Bart Barlogie; Faith E Davies; Gareth J Morgan; Shmuel Yaccoby
Journal:  Br J Haematol       Date:  2018-11-08       Impact factor: 6.998

3.  MYH9 binds to lncRNA gene PTCSC2 and regulates FOXE1 in the 9q22 thyroid cancer risk locus.

Authors:  Yanqiang Wang; Huiling He; Wei Li; John Phay; Rulong Shen; Lianbo Yu; Baris Hancioglu; Albert de la Chapelle
Journal:  Proc Natl Acad Sci U S A       Date:  2017-01-03       Impact factor: 11.205

Review 4.  Estrogen Receptor-β and the Insulin-Like Growth Factor Axis as Potential Therapeutic Targets for Triple-Negative Breast Cancer.

Authors:  Nalo Hamilton; Diana Marquez-Garban; Vei H Mah; Yahya Elshimali; David Elashoff; Edward B Garon; Jaydutt Vadgama; Richard Pietras
Journal:  Crit Rev Oncog       Date:  2015

5.  High-Resolution Bisulfite-Sequencing of Peripheral Blood DNA Methylation in Early-Onset and Familial Risk Breast Cancer Patients.

Authors:  Justin Chen; Maria K Haanpää; Joshua J Gruber; Natalie Jäger; James M Ford; Michael P Snyder
Journal:  Clin Cancer Res       Date:  2019-06-07       Impact factor: 12.531

6.  Akt signaling dynamics in individual cells.

Authors:  Sean M Gross; Peter Rotwein
Journal:  J Cell Sci       Date:  2015-06-03       Impact factor: 5.285

7.  Nuclear FAK and Runx1 Cooperate to Regulate IGFBP3, Cell-Cycle Progression, and Tumor Growth.

Authors:  Marta Canel; Adam Byron; Andrew H Sims; Jessy Cartier; Hitesh Patel; Margaret C Frame; Valerie G Brunton; Bryan Serrels; Alan Serrels
Journal:  Cancer Res       Date:  2017-08-14       Impact factor: 12.701

Review 8.  Insulin/IGF signaling in Drosophila and other insects: factors that regulate production, release and post-release action of the insulin-like peptides.

Authors:  Dick R Nässel; Jozef Vanden Broeck
Journal:  Cell Mol Life Sci       Date:  2015-10-15       Impact factor: 9.261

9.  Dietary tomato and lycopene impact androgen signaling- and carcinogenesis-related gene expression during early TRAMP prostate carcinogenesis.

Authors:  Lei Wan; Hsueh-Li Tan; Jennifer M Thomas-Ahner; Dennis K Pearl; John W Erdman; Nancy E Moran; Steven K Clinton
Journal:  Cancer Prev Res (Phila)       Date:  2014-10-14

10.  Dual Targeting of EGFR and IGF1R in the TNFAIP8 Knockdown Non-Small Cell Lung Cancer Cells.

Authors:  Timothy F Day; Bhaskar V S Kallakury; Jeffrey S Ross; Olga Voronel; Shantashri Vaidya; Christine E Sheehan; Usha N Kasid
Journal:  Mol Cancer Res       Date:  2019-01-15       Impact factor: 5.852
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