Literature DB >> 2472214

Supercomputer analysis of purine and pyrimidine metabolism leading to DNA synthesis.

F Heinmets.   

Abstract

A model-system is established to analyze purine and pyrimidine metabolism leading to DNA synthesis. The principal aim is to explore the flow and regulation of terminal deoxynucleoside triophosphates (dNTPs) in various input and parametric conditions. A series of flow equations are established, which are subsequently converted to differential equations. These are programmed (Fortran) and analyzed on a Cray chi-MP/48 supercomputer. The pool concentrations are presented as a function of time in conditions in which various pertinent parameters of the system are modified. The system is formulated by 100 differential equations.

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Year:  1989        PMID： 2472214     DOI： 10.1007/BF02797274

Source DB:  PubMed          Journal:  Cell Biophys        ISSN： 0163-4992


  29 in total

Review 1.  From deoxynucleotides to DNA synthesis.

Authors:  P Reichard
Journal:  Fed Proc       Date:  1978-01

2.  The induction of differentiation in teratocarcinoma stem cells by retinoic acid.

Authors:  S Strickland; V Mahdavi
Journal:  Cell       Date:  1978-10       Impact factor: 41.582

Review 3.  Cell differentiation and bypassing of genetic defects in the suppression of malignancy.

Authors:  L Sachs
Journal:  Cancer Res       Date:  1987-04-15       Impact factor: 12.701

Review 4.  Molecules involved in proliferation of normal and cancer cells: presidential address.

Authors:  A B Pardee
Journal:  Cancer Res       Date:  1987-03-15       Impact factor: 12.701

5.  Cell cycle analysis during retinoic acid induced differentiation of a human embryonal carcinoma-derived cell line.

Authors:  C L Mummery; M A van Rooijen; S E van den Brink; S W de Laat
Journal:  Cell Differ       Date:  1987-03

6.  Ribonucleotide reductase and thymidine kinase activities in various cultured cell lines derived from hematologic malignancies.

Authors:  E Takeda; M Hirose; Y Kuroda; T Ninomiya; K Toshima; T Watanabe; M Ito; E Naito; M Miyao
Journal:  Gan       Date:  1984-09

7.  Identification and quantitation of adenine deoxynucleotides in erythrocytes of a patient with adenosine deaminase deficiency and severe combined immunodeficiency.

Authors:  M S Coleman; J Donofrio; J J Hutton; L Hahn; A Daoud; B Lampkin; J Dyminski
Journal:  J Biol Chem       Date:  1978-03-10       Impact factor: 5.157

8.  Regulation of thymidine kinase activity in the cell cycle by a labile protein.

Authors:  D L Coppock; A B Pardee
Journal:  J Cell Physiol       Date:  1985-08       Impact factor: 6.384

9.  Relative activities of thymidylate synthetase and thymidine kinase in 1,2-dimethylhydrazine-induced colon carcinomas in rats.

Authors:  S Sakamoto; K Kuwa; K Tsukada; T Sagara; N Kasahara; R Okamoto
Journal:  Carcinogenesis       Date:  1987-03       Impact factor: 4.944

10.  Cell differentiation and malignancy.

Authors:  L Sachs
Journal:  Cell Biophys       Date:  1986-12
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  2 in total

1.  A study of deoxyribonucleotide metabolism and its relation to DNA synthesis. Supercomputer simulation and model-system analysis.

Authors:  F Heinmets; R H Leary
Journal:  Cell Biophys       Date:  1991-06

2.  Validation and steady-state analysis of a power-law model of purine metabolism in man.

Authors:  R Curto; E O Voit; A Sorribas; M Cascante
Journal:  Biochem J       Date:  1997-06-15       Impact factor: 3.857
  2 in total

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