Bobby A Tajudeen1, Jennifer Fuller2, Chi Lai2, Tristan Grogan3, David Elashoff4, Elliot Abemayor5, Maie St John6. 1. Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; UCLA Head and Neck Cancer Program, David Geffen School of Medicine at UCLA, Los Angeles, CA. 2. Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA. 3. Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, CA. 4. Department of Medicine Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, CA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA. 5. Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA; UCLA Head and Neck Cancer Program, David Geffen School of Medicine at UCLA, Los Angeles, CA. 6. Department of Head and Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA; UCLA Head and Neck Cancer Program, David Geffen School of Medicine at UCLA, Los Angeles, CA. Electronic address: mstjohn@mednet.ucla.edu.
Abstract
PURPOSE: To profile the clinical presentation, subtype distribution, and treatment results of sarcomas of the head and neck at a single tertiary academic center over an 11-year period. MATERIALS AND METHODS: A retrospective review was performed by examining the records and reviewing the pathology of 186 patients with head and neck sarcomas treated at UCLA Medical Center from 2000 to 2011. RESULTS: The mean age of the study population was 49 ± 22 years. 58% of the patients were male and 42% were female. Median duration of follow-up for the entire group was 18.5 months. The most common presenting symptom was a mass lesion in 59.9% of patients. The nasal cavity/sinus was the most common presenting site seen in 22% of patients. Solitary fibrous tumor/hemangiopericytoma was the most common subtype. 15% of patients had evidence of prior radiation exposure. 26.3% of tumors were greater than 5 cm and 35.5% were high-grade. Margins were positive in 31.2% of patients. Lymph node metastasis was rare at 6.5%. Perineural invasion was identified in 6.5%. Among all subtypes, 5-year recurrence-free survival and overall survival were 50% and 49%, respectively. Multivariate analysis demonstrated that grade and margin status were predictors of recurrence-free survival while grade and age affected overall survival. CONCLUSIONS: Head and neck sarcomas are a rare entity frequently presenting as a mass lesion. In our series, lesions tended to be high-grade with a significant portion of surgical specimens having positive margins. Grade and margin status were the most important predictors of survival.
PURPOSE: To profile the clinical presentation, subtype distribution, and treatment results of sarcomas of the head and neck at a single tertiary academic center over an 11-year period. MATERIALS AND METHODS: A retrospective review was performed by examining the records and reviewing the pathology of 186 patients with head and neck sarcomas treated at UCLA Medical Center from 2000 to 2011. RESULTS: The mean age of the study population was 49 ± 22 years. 58% of the patients were male and 42% were female. Median duration of follow-up for the entire group was 18.5 months. The most common presenting symptom was a mass lesion in 59.9% of patients. The nasal cavity/sinus was the most common presenting site seen in 22% of patients. Solitary fibrous tumor/hemangiopericytoma was the most common subtype. 15% of patients had evidence of prior radiation exposure. 26.3% of tumors were greater than 5 cm and 35.5% were high-grade. Margins were positive in 31.2% of patients. Lymph node metastasis was rare at 6.5%. Perineural invasion was identified in 6.5%. Among all subtypes, 5-year recurrence-free survival and overall survival were 50% and 49%, respectively. Multivariate analysis demonstrated that grade and margin status were predictors of recurrence-free survival while grade and age affected overall survival. CONCLUSIONS: Head and neck sarcomas are a rare entity frequently presenting as a mass lesion. In our series, lesions tended to be high-grade with a significant portion of surgical specimens having positive margins. Grade and margin status were the most important predictors of survival.
Authors: R B Raney; J R Anderson; F G Barr; S S Donaldson; A S Pappo; S J Qualman; E S Wiener; H M Maurer; W M Crist Journal: J Pediatr Hematol Oncol Date: 2001-05 Impact factor: 1.289
Authors: Mohemmed N Khan; Qasim Husain; Vivek V Kanumuri; Zain Boghani; Chirag R Patel; James K Liu; Jean Anderson Eloy Journal: Int Forum Allergy Rhinol Date: 2013-03-20 Impact factor: 3.858
Authors: David V Cashen; Robert C Parisien; Kevin Raskin; Francis J Hornicek; Mark C Gebhardt; Henry J Mankin Journal: Clin Orthop Relat Res Date: 2004-09 Impact factor: 4.176
Authors: Brandon G Bentz; Bhuvanesh Singh; James Woodruff; Murray Brennan; Jatin P Shah; Dennis Kraus Journal: Ann Surg Oncol Date: 2004-06 Impact factor: 5.344
Authors: Ho-Seok Sa; Maria Laura Rubin; Jing Ning; Wen Li; Michael T Tetzlaff; Susan L McGovern; Arnold C Paulino; Cynthia E Herzog; Jonathan B Gill; Bita Esmaeli Journal: JAMA Ophthalmol Date: 2020-04-01 Impact factor: 7.389