Literature DB >> 24720538

Therapeutical potential of CB₂ receptors in immune-related diseases.

Natascha Leleu-Chavain, Pierre Desreumaux, Philippe Chavatte, Régis Millet1.   

Abstract

The cannabinoid receptor CB2 is highly expressed in immune cells suggesting an important role in numerous diseases such as inflammation, cancer, osteoporosis and liver diseases relating to modulation of the immune system. As a consequence, activation of receptor CB2 is a promising therapeutic strategy for the treatment of a large range of diseases. Indeed, selective CB2 agonists display beneficial anti-inflammatory, anti-cancer and antifibrogenic properties and positive effects on liver disease and osteoporosis. This article reviews the CB2 involvement in the immune system and the promising therapeutical potential of selective CB2 agonists in the treatment of several immune-related diseases.

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Year:  2013        PMID： 24720538     DOI： 10.2174/1874467207666140219122337

Source DB:  PubMed          Journal:  Curr Mol Pharmacol        ISSN： 1874-4672            Impact factor:   3.339


  9 in total

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