Literature DB >> 2471514

Inhibition of aspartic proteinases by alpha 2-macroglobulin.

D J Thomas1, A D Richards, J Kay.   

Abstract

The effect of alpha 2-macroglobulin, one of the major antiproteinases in the plasma of vertebrates, on the action of the aspartic proteinases chymosin, cathepsin D and cathepsin E towards peptide and protein substrates at pH 6.2 was examined. Activities towards protein substrates were blocked, thus demonstrating that alpha 2-macroglobulin can inhibit aspartic proteinases, in addition to serine proteinases, cysteine proteinases and metalloproteinases.

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Year:  1989        PMID： 2471514      PMCID： PMC1138603          DOI： 10.1042/bj2590905

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  10 in total

1.  The autoactivation of trypsinogen.

Authors:  J Kay; B Kassell
Journal:  J Biol Chem       Date:  1971-11       Impact factor: 5.157

2.  Stabilisation of cathepsin E by ATP.

Authors:  D J Thomas; A D Richards; R A Jupp; E Ueno; K Yamamoto; I M Samloff; B M Dunn; J Kay
Journal:  FEBS Lett       Date:  1989-01-30       Impact factor: 4.124

3.  A turbidimetric milk-clotting assay for pepsin.

Authors:  P McPhie
Journal:  Anal Biochem       Date:  1976-05-21       Impact factor: 3.365

4.  Proteolysis--a degrading business but food for thought.

Authors:  J Kay
Journal:  Biochem Soc Trans       Date:  1982-08       Impact factor: 5.407

5.  Regulation of proteolysis: implications for the control of protein breakdown within the cell.

Authors:  J Kay
Journal:  Biochem Soc Trans       Date:  1980-08       Impact factor: 5.407

6.  Identification of the aspartic proteinases from human erythrocyte membranes and gastric mucosa (slow-moving proteinase) as catalytically equivalent to cathepsin E.

Authors:  R A Jupp; A D Richards; J Kay; B M Dunn; J B Wyckoff; I M Samloff; K Yamamoto
Journal:  Biochem J       Date:  1988-09-15       Impact factor: 3.857

7.  The pH dependence of the hydrolysis of chromogenic substrates of the type, Lys-Pro-Xaa-Yaa-Phe-(NO2)Phe-Arg-Leu, by selected aspartic proteinases: evidence for specific interactions in subsites S3 and S2.

Authors:  B M Dunn; M J Valler; C E Rolph; S I Foundling; M Jimenez; J Kay
Journal:  Biochim Biophys Acta       Date:  1987-06-17

8.  Immunolocalization of cathepsin D in normal and neoplastic human tissues.

Authors:  W A Reid; M J Valler; J Kay
Journal:  J Clin Pathol       Date:  1986-12       Impact factor: 3.411

9.  A systematic series of synthetic chromophoric substrates for aspartic proteinases.

Authors:  B M Dunn; M Jimenez; B F Parten; M J Valler; C E Rolph; J Kay
Journal:  Biochem J       Date:  1986-08-01       Impact factor: 3.857

10.  The interaction of alpha 2-macroglobulin with proteinases. Characteristics and specificity of the reaction, and a hypothesis concerning its molecular mechanism.

Authors:  A J Barrett; P M Starkey
Journal:  Biochem J       Date:  1973-08       Impact factor: 3.857
  10 in total
  3 in total

1.  Differential therapeutic responses of thiol compounds in the reversal of methylmercury inhibited acid phosphatase and cathepsin E in the central nervous system of rat.

Authors:  S D Vinay; K G Raghu; P P Sood
Journal:  Bull Environ Contam Toxicol       Date:  1992-07       Impact factor: 2.151

Review 2.  The early and late processing of lysosomal enzymes: proteolysis and compartmentation.

Authors:  A Hasilik
Journal:  Experientia       Date:  1992-02-15

3.  Genome-wide identification and immune response analysis of serine protease inhibitor genes in the silkworm, Bombyx mori.

Authors:  Ping Zhao; Zhaoming Dong; Jun Duan; Genhong Wang; Lingyan Wang; Youshan Li; Zhonghuai Xiang; Qingyou Xia
Journal:  PLoS One       Date:  2012-02-13       Impact factor: 3.240
  3 in total

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