Literature DB >> 24711286

1958-2014: after 56 years of research, cytochrome p450 reactivity is finally explained.

Ashley B McQuarters1, Matthew W Wolf, Andrew P Hunt, Nicolai Lehnert.   

Abstract

Nature's wisdom in enzyme design: Compounds I and II in the catalytic cycle of the Cytochrome P450 enzymes have been trapped and characterized recently. This work has provided further insight into the electronic structure and reactivity of these crucial intermediates, and key questions regarding the mechanism of these enzymes have finally been answered.
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  Cytochrome P450; CH bond activation; hydroxylation; monooxygenases

Mesh：

Substances：

Year:  2014        PMID： 24711286     DOI： 10.1002/anie.201402404

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  18 in total

Review 1.  Spectroscopic studies of the cytochrome P450 reaction mechanisms.

Authors:  Piotr J Mak; Ilia G Denisov
Journal:  Biochim Biophys Acta Proteins Proteom       Date:  2017-06-28       Impact factor: 3.036

Review 2.  Human cytochrome P450 enzymes 5-51 as targets of drugs and natural and environmental compounds: mechanisms, induction, and inhibition - toxic effects and benefits.

Authors:  Slobodan P Rendic; F Peter Guengerich
Journal:  Drug Metab Rev       Date:  2018-08       Impact factor: 4.518

Review 3.  Elaboration of copper-oxygen mediated C-H activation chemistry in consideration of future fuel and feedstock generation.

Authors:  Jung Yoon Lee; Kenneth D Karlin
Journal:  Curr Opin Chem Biol       Date:  2015-03-08       Impact factor: 8.822

4.  Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin.

Authors:  Qianhong Zhu; Piotr J Mak; Robert C Tuckey; James R Kincaid
Journal:  Biochemistry       Date:  2017-10-20       Impact factor: 3.162

Review 5.  Biological and Bioinspired Inorganic N-N Bond-Forming Reactions.

Authors:  Christina Ferousi; Sean H Majer; Ida M DiMucci; Kyle M Lancaster
Journal:  Chem Rev       Date:  2020-02-28       Impact factor: 60.622

6.  Heme-FeIII Superoxide, Peroxide and Hydroperoxide Thermodynamic Relationships: FeIII-O2•- Complex H-Atom Abstraction Reactivity.

Authors:  Hyun Kim; Patrick J Rogler; Savita K Sharma; Andrew W Schaefer; Edward I Solomon; Kenneth D Karlin
Journal:  J Am Chem Soc       Date:  2020-01-28       Impact factor: 15.419

7.  Copper(I)-Dioxygen Adducts and Copper Enzyme Mechanisms.

Authors:  Jeffrey J Liu; Daniel E Diaz; David A Quist; Kenneth D Karlin
Journal:  Isr J Chem       Date:  2016-07-26       Impact factor: 3.333

8.  Probing the Mechanism of Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.

Authors:  Antonio Del Rio Flores; David W Kastner; Yongle Du; Maanasa Narayanamoorthy; Yuanbo Shen; Wenlong Cai; Vyshnavi Vennelakanti; Nicholas A Zill; Luisa B Dell; Rui Zhai; Heather J Kulik; Wenjun Zhang
Journal:  J Am Chem Soc       Date:  2022-03-07       Impact factor: 15.419

9.  Cholesterol hydroperoxides as substrates for cholesterol-metabolizing cytochrome P450 enzymes and alternative sources of 25-hydroxycholesterol and other oxysterols.

Authors:  Johan E van Lier; Natalia Mast; Irina A Pikuleva
Journal:  Angew Chem Int Ed Engl       Date:  2015-07-29       Impact factor: 15.336

10.  Reactivity of a Cobalt(III)-Hydroperoxo Complex in Electrophilic Reactions.

Authors:  Bongki Shin; Kyle D Sutherlin; Takehiro Ohta; Takashi Ogura; Edward I Solomon; Jaeheung Cho
Journal:  Inorg Chem       Date:  2016-11-15       Impact factor: 5.165
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