Keiji Nagata1, Noriko Yoshimura2, Hiroshi Hashizume3, Shigeyuki Muraki4, Yuyu Ishimoto1, Hiroshi Yamada1, Noboru Takiguchi1, Yukihiro Nakagawa1, Akihito Minamide1, Hiroyuki Oka2, Hiroshi Kawaguchi5, Kozo Nakamura6, Toru Akune4, Munehito Yoshida1. 1. Department of Orthopaedic Surgery, Wakayama Medical University, 811-1, Kimiidera, Wakayama City, 641-8510, Japan. 2. Department of Joint Disease Research, 22nd Century Medical and Research Center, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan. 3. Department of Orthopaedic Surgery, Wakayama Medical University, 811-1, Kimiidera, Wakayama City, 641-8510, Japan. Electronic address: hashizum@wakayama-med.ac.jp. 4. Department of Clinical Motor System Medicine, 22nd Century Medical & Research Center, Faculty of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo, 113-8654, Japan. 5. Japan Community Health Care Organization Tokyo Shinjuku Medical Center, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan. 6. Rehabilitation Services Bureau, National Rehabilitation Center for Persons with Disabilities, 1, Namiki 4-chome, Tokorozawa City, Saitama Prefecture 359-8555, Japan.
Abstract
BACKGROUND CONTEXT: A narrow cervical spinal canal (CSC) is a well-known risk factor for cervical myelopathy (CM). However, no epidemiologic data of the CSC based on a population-based cohort are available. PURPOSE: The purpose of the study was to investigate the age-related differences in CSC diameters on plain radiographs and to examine the associated magnetic resonance imaging (MRI) abnormalities including cervical cord compression and increased signal intensity (ISI) as well as the clinical CM with the narrow CSC. STUDY DESIGN/ SETTING: This was a cross-sectional study. PARTICIPANT SAMPLE: Data were obtained from the baseline survey of the Wakayama Spine Study that was performed from 2008 to 2010 in a western part of Japan. Finally, a total of 959 subjects (319 men and 640 women; mean age, 66.4 years) were included. OUTCOME MEASURES: The outcome measures included in the study were the CSC diameter at C5 level on plain radiographs, cervical cord compression and ISI on sagittal T2-weighted MRI, and physical signs related to CM (eg, the Hoffmann reflex, hyperreflexia of the patellar tendon, the Babinski reflex, sensory and motor function, and bowel/bladder symptoms). METHODS: The age-related differences of CSC diameters in men and women were investigated by descriptive statistics. The prevalence of MRI abnormalities and clinical CM was compared among the groups divided by the CSC diameter (less than 13, 13-15, and 15 mm or more). In addition, a logistic regression analysis was performed to determine the association of the CSC diameter with cervical cord compression/clinical CM after overall adjustment for age, sex, and body mass index. RESULTS: The CSC diameter was narrower with increasing age in both men and women. The prevalence of cervical cord compression, ISI, and the clinical CM was significantly higher in the narrower CSC group. The prevalence of cervical cord compression, ISI, and CM among subjects with CSC diameter less than 13 mm was 38.0%, 5.4%, and 10.1%, respectively. In the logistic model, the CSC diameter was a significant predictive factor for the clinical CM (p<.0001). CONCLUSIONS: This study firstly confirmed the age-related differences in CSC diameters and the significant association of the narrow CSC diameter with CM in a population-based cohort.
BACKGROUND CONTEXT: A narrow cervical spinal canal (CSC) is a well-known risk factor for cervical myelopathy (CM). However, no epidemiologic data of the CSC based on a population-based cohort are available. PURPOSE: The purpose of the study was to investigate the age-related differences in CSC diameters on plain radiographs and to examine the associated magnetic resonance imaging (MRI) abnormalities including cervical cord compression and increased signal intensity (ISI) as well as the clinical CM with the narrow CSC. STUDY DESIGN/ SETTING: This was a cross-sectional study. PARTICIPANT SAMPLE: Data were obtained from the baseline survey of the Wakayama Spine Study that was performed from 2008 to 2010 in a western part of Japan. Finally, a total of 959 subjects (319 men and 640 women; mean age, 66.4 years) were included. OUTCOME MEASURES: The outcome measures included in the study were the CSC diameter at C5 level on plain radiographs, cervical cord compression and ISI on sagittal T2-weighted MRI, and physical signs related to CM (eg, the Hoffmann reflex, hyperreflexia of the patellar tendon, the Babinski reflex, sensory and motor function, and bowel/bladder symptoms). METHODS: The age-related differences of CSC diameters in men and women were investigated by descriptive statistics. The prevalence of MRI abnormalities and clinical CM was compared among the groups divided by the CSC diameter (less than 13, 13-15, and 15 mm or more). In addition, a logistic regression analysis was performed to determine the association of the CSC diameter with cervical cord compression/clinical CM after overall adjustment for age, sex, and body mass index. RESULTS: The CSC diameter was narrower with increasing age in both men and women. The prevalence of cervical cord compression, ISI, and the clinical CM was significantly higher in the narrower CSC group. The prevalence of cervical cord compression, ISI, and CM among subjects with CSC diameter less than 13 mm was 38.0%, 5.4%, and 10.1%, respectively. In the logistic model, the CSC diameter was a significant predictive factor for the clinical CM (p<.0001). CONCLUSIONS: This study firstly confirmed the age-related differences in CSC diameters and the significant association of the narrow CSC diameter with CM in a population-based cohort.
Authors: Vijay M Ravindra; Steven S Senglaub; Abbas Rattani; Michael C Dewan; Roger Härtl; Erica Bisson; Kee B Park; Mark G Shrime Journal: Global Spine J Date: 2018-04-24
Authors: Christopher Nell; Robin Bülow; Norbert Hosten; Carsten Oliver Schmidt; Katrin Hegenscheid Journal: PLoS One Date: 2019-09-27 Impact factor: 3.240