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Literature DB >> 2470598

Ruthenium red selectively prevents capsaicin-induced nociceptor stimulation.

Abstract

The effect of Ruthenium Red on capsaicin-induced stimulation of polymodal nociceptors was investigated in the isolated perfused rabbit ear with an intact neuronal connection. Ruthenium Red, 20 microM, completely prevented the response to capsaicin but not that to acetylcholine or bradykinin. It is therefore suggested that capsaicin activates sensory nerve terminals by a mechanism which is different from that for bradykinin or acetylcholine, and which can be blocked selectively by Ruthenium Red.

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Year: 1989 PMID： 2470598 DOI： 10.1016/0014-2999(89)90849-2

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

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Cited

13 in total

1. Effect of nedocromil sodium on allergen-, PAF-, histamine- and bradykinin-induced airways vasodilatation and pulmonary obstruction in the pig.

Authors: K Alving; R Matran; J M Lundberg
Journal: Br J Pharmacol Date: 1991-10 Impact factor: 8.739

2. Ruthenium red selectively inhibits oedema formation and increased blood flow induced by capsaicin in rabbit skin.

Authors: T L Buckley; S D Brain; T J Williams
Journal: Br J Pharmacol Date: 1990-01 Impact factor: 8.739

3. Sensory nerves, vascular endothelium and neurogenic relaxation of the guinea-pig isolated pulmonary artery.

Authors: C A Maggi; R Patacchini; F Perretti; M Tramontana; S Manzini; P Geppetti; P Santicioli
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1990-07 Impact factor: 3.000

4. Activation of primary afferent neurons by thermal stimulation. Influence of ruthenium red.

Authors: R Amann; J Donnerer; F Lembeck
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1990 Jan-Feb Impact factor: 3.000

5. Effects of neuropeptides, ruthenium red and neuraminidase on chemoreflexes mediated by afferents in the dog epicardium.

Authors: J Staszewska-Woolley; G Woolley
Journal: J Physiol Date: 1991-05 Impact factor: 5.182

6. Modulation of a voltage-gated calcium channel linked to activation of glutamate receptors and calcium-induced calcium release in the catfish retina.

Authors: C L Linn; A C Gafka
Journal: J Physiol Date: 2001-08-15 Impact factor: 5.182

Ruthenium red selectively prevents capsaicin-induced nociceptor stimulation.

1. Effect of nedocromil sodium on allergen-, PAF-, histamine- and bradykinin-induced airways vasodilatation and pulmonary obstruction in the pig.

2. Ruthenium red selectively inhibits oedema formation and increased blood flow induced by capsaicin in rabbit skin.

3. Sensory nerves, vascular endothelium and neurogenic relaxation of the guinea-pig isolated pulmonary artery.

4. Activation of primary afferent neurons by thermal stimulation. Influence of ruthenium red.

5. Effects of neuropeptides, ruthenium red and neuraminidase on chemoreflexes mediated by afferents in the dog epicardium.

6. Modulation of a voltage-gated calcium channel linked to activation of glutamate receptors and calcium-induced calcium release in the catfish retina.

7. Calcitonin gene-related peptide and human epicardial coronary arteries: presence, release and vasodilator effects.

8. Contribution of TRPV1 to microglia-derived IL-6 and NFkappaB translocation with elevated hydrostatic pressure.

9. Capsazepine: a competitive antagonist of the sensory neurone excitant capsaicin.

10. Capsaicin-desensitization to the human nasal mucosa selectively reduces pain evoked by citric acid.