Literature DB >> 1691945

Ruthenium red selectively inhibits oedema formation and increased blood flow induced by capsaicin in rabbit skin.

T L Buckley1, S D Brain, T J Williams.   

Abstract

It has been suggested that ruthenium red has a selective inhibitory effect on capsaicin-induced nociceptor stimulation. We have investigated the effect of ruthenium red on oedema formation and vasodilatation induced by intradermal (i.d.) injection of capsaicin in the rabbit in vivo. Responses induced by capsaicin were inhibited by ruthenium red, but responses induced by bradykinin, N-formyl-methionyl-leucyl-phenylalanine (FMLP), platelet activating factor (PAF), histamine and calcitonin gene-related peptide (CGRP) were not affected. These results suggest that ruthenium red selectively inhibits capsaicin-induced local plasma protein leakage and vasodilatation in the rabbit skin microvasculature.

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Year:  1990        PMID： 1691945      PMCID： PMC1917495          DOI： 10.1111/j.1476-5381.1990.tb14642.x

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  10 in total

1.  Multiple tachykinin pools in sensory nerve fibres in the rabbit iris.

Authors:  R Håkanson; B Beding; R Ekman; M Heilig; C Wahlestedt; F Sundler
Journal:  Neuroscience       Date:  1987-06       Impact factor: 3.590

2.  A comparison of bradykinin- and capsaicin-induced myocardial and coronary effects in isolated perfused heart of guinea-pig: involvement of substance P and calcitonin gene-related peptide release.

Authors:  S Manzini; F Perretti; L De Benedetti; P Pradelles; C A Maggi; P Geppetti
Journal:  Br J Pharmacol       Date:  1989-06       Impact factor: 8.739

3.  The antagonism induced by ruthenium red of the actions of capsaicin on the peripheral terminals of sensory neurons: further studies.

Authors:  C A Maggi; P Santicioli; P Geppetti; M Parlani; M Astolfi; P Pradelles; R Patacchini; A Meli
Journal:  Eur J Pharmacol       Date:  1988-09-01       Impact factor: 4.432

4.  Ruthenium red selectively prevents capsaicin-induced nociceptor stimulation.

Authors:  R Amann; F Lembeck
Journal:  Eur J Pharmacol       Date:  1989-02-28       Impact factor: 4.432

5.  Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation.

Authors:  T J Williams
Journal:  Br J Pharmacol       Date:  1979-03       Impact factor: 8.739

6.  The mechanism of action of capsaicin on sensory C-type neurons and their axons in vitro.

Authors:  S J Marsh; C E Stansfeld; D A Brown; R Davey; D McCarthy
Journal:  Neuroscience       Date:  1987-10       Impact factor: 3.590

7.  Binding of lanthanum ions and ruthenium red to synaptosomes and its effects on neurotransmitter release.

Authors:  R Tapia; C Arias; E Morales
Journal:  J Neurochem       Date:  1985-11       Impact factor: 5.372

8.  Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability.

Authors:  S D Brain; T J Williams
Journal:  Br J Pharmacol       Date:  1985-12       Impact factor: 8.739

Review 9.  The sensory-efferent function of capsaicin-sensitive sensory neurons.

Authors:  C A Maggi; A Meli
Journal:  Gen Pharmacol       Date:  1988

10.  Calcitonin gene-related peptide is a potent vasodilator.

Authors:  S D Brain; T J Williams; J R Tippins; H R Morris; I MacIntyre
Journal:  Nature       Date:  1985 Jan 3-9       Impact factor: 49.962
  10 in total
  7 in total

1.  Effects of ruthenium red and capsazepine on C-fibres in the rabbit iris.

Authors:  Z Y Wang; R Håkanson
Journal:  Br J Pharmacol       Date:  1993-11       Impact factor: 8.739

2.  Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways.

Authors:  I D Chapman; A Kristersson; G Mathelin; E Schaeublin; L Mazzoni; K Boubekeur; N Murphy; J Morley
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

3.  Maintenance of functional activity of human pulmonary arteries after cryopreservation.

Authors:  P Ellis; E Müller-Schweinitzer
Journal:  Br J Pharmacol       Date:  1991-06       Impact factor: 8.739

4.  [3H]resiniferatoxin binding by the vanilloid receptor: species-related differences, effects of temperature and sulfhydryl reagents.

Authors:  A Szallasi; P M Blumberg
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-01       Impact factor: 3.000

5.  Hypotensive effect of 13-hydroxylinoleic acid in the rat: mediation via the release of a CGRP-like mediator from capsaicin-sensitive nerves.

Authors:  D van Heuven-Nolsen; T Muis; F Engels; P A Henricks; T L Buckley; F P Nijkamp
Journal:  Br J Pharmacol       Date:  1995-07       Impact factor: 8.739

6.  An investigation into the mechanism of capsaicin-induced oedema in rabbit skin.

Authors:  P Newbold; S D Brain
Journal:  Br J Pharmacol       Date:  1995-02       Impact factor: 8.739

7.  Ruthenium red antagonism of capsaicin-induced vascular changes in the rat nasal mucosa.

Authors:  F Bari; G Jancsó
Journal:  Eur Arch Otorhinolaryngol       Date:  1994       Impact factor: 2.503
  7 in total

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