Masatoshi Kondo1, Michinobu Nagao2, Masato Yonezawa3, Yuzo Yamazaki3, Takashi Shirasaka4, Yasuhiko Nakamura4, Hiroshi Honda3. 1. Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-Ku, Fukuoka City, Fukuoka 812-8582, Japan. Electronic address: m-kondo@med.kyushu-u.ac.jp. 2. Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan. 3. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan. 4. Department of Medical Technology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-Ku, Fukuoka City, Fukuoka 812-8582, Japan.
Abstract
RATIONALE AND OBJECTIVES: To investigate the effect of dual-bolus contrast media injection (dual-CM) on the accuracy of automated right ventricular (RV) segmentation on coronary computed tomography angiography (CCTA). MATERIALS AND METHODS: A total of 104 patients with suspected and known coronary artery disease underwent 256-slice CCTA with retrospective electrocardiographic (ECG) gating. The patients were divided into 51 patients who underwent single-bolus CM injection (single-CM) and 53 patients who underwent dual-CM. The dual-CM method consisted of an initial bolus of CM followed by an injection of dilute CM with saline (CM:saline, 1:9). Three-dimensional CCTA images were automatically segmented into the RV, left ventricle (LV), and myocardium using commercially available software (Comprehensive Cardiac Analysis; Philips Medical Systems, Cleveland, OH). Prevalence and locations of segmentation errors were compared between single-CM and dual-CM. Segmentation errors were defined as segment deviation of >1 cm from the actual ventricular margin. RESULTS: Prevalence of segmentation errors was significantly lower with dual-CM than with single-CM in the diastolic phase (4/41 vs. 20/41, respectively; P < .01), and there was no difference between the two methods in the systolic phase (2/12 vs. 2/10, respectively). With dual-CM and single-CM, the locations of segmentation errors were mostly the RV wall (4/53 and 18/51, respectively) and secondly the LV wall (2/53 and 9/51, respectively). CONCLUSIONS: Dual-CM improved the accuracy of automated ventricular segmentation using diastolic data from 256-slice CCTA.
RATIONALE AND OBJECTIVES: To investigate the effect of dual-bolus contrast media injection (dual-CM) on the accuracy of automated right ventricular (RV) segmentation on coronary computed tomography angiography (CCTA). MATERIALS AND METHODS: A total of 104 patients with suspected and known coronary artery disease underwent 256-slice CCTA with retrospective electrocardiographic (ECG) gating. The patients were divided into 51 patients who underwent single-bolus CM injection (single-CM) and 53 patients who underwent dual-CM. The dual-CM method consisted of an initial bolus of CM followed by an injection of dilute CM with saline (CM:saline, 1:9). Three-dimensional CCTA images were automatically segmented into the RV, left ventricle (LV), and myocardium using commercially available software (Comprehensive Cardiac Analysis; Philips Medical Systems, Cleveland, OH). Prevalence and locations of segmentation errors were compared between single-CM and dual-CM. Segmentation errors were defined as segment deviation of >1 cm from the actual ventricular margin. RESULTS: Prevalence of segmentation errors was significantly lower with dual-CM than with single-CM in the diastolic phase (4/41 vs. 20/41, respectively; P < .01), and there was no difference between the two methods in the systolic phase (2/12 vs. 2/10, respectively). With dual-CM and single-CM, the locations of segmentation errors were mostly the RV wall (4/53 and 18/51, respectively) and secondly the LV wall (2/53 and 9/51, respectively). CONCLUSIONS: Dual-CM improved the accuracy of automated ventricular segmentation using diastolic data from 256-slice CCTA.