Literature DB >> 24703347

The genetic basis of gout.

Tony R Merriman1, Hyon K Choi2, Nicola Dalbeth3.   

Abstract

Gout results from deposition of monosodium urate (MSU) crystals. Elevated serum urate concentrations (hyperuricemia) are not sufficient for the development of disease. Genome-wide association studies (GWAS) have identified 28 loci controlling serum urate levels. The largest genetic effects are seen in genes involved in the renal excretion of uric acid, with others being involved in glycolysis. Whereas much is understood about the genetic control of serum urate levels, little is known about the genetic control of inflammatory responses to MSU crystals. Extending knowledge in this area depends on recruitment of large, clinically ascertained gout sample sets suitable for GWAS.
Copyright © 2014 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  ABCG2; Association; Gene; Genome-wide association studies; Gout; SLC2A9; Urate

Mesh：

Substances：

Year:  2014        PMID： 24703347     DOI： 10.1016/j.rdc.2014.01.009

Source DB:  PubMed          Journal:  Rheum Dis Clin North Am        ISSN： 0889-857X            Impact factor:   2.670


  16 in total

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Review 3.  Gout: a review of nonmodifiable and modifiable risk factors.

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